Evidence map›Paper›PMID 31712878›Full record

SynthesisEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2020

Risk factors of pharyngocutaneous fistula after total laryngectomy: a systematic review and meta-analysis.

Maohua Wang, Youfang Xun, Kaijian Wang, Ling Lu, Aimin Yu, Bing Guan, Chenjie Yu

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07241611 (Role of Cervical Fascia Flap in Decreasing the Incidence of Pharyngocutaneous Fistula After Total Laryngectomy), which is not on this map. Cited by 42 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 2 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07241611 nacompletednot on this mapstarted 2024, after this paper: background citation

Role of Cervical Fascia Flap in Decreasing the Incidence of Pharyngocutaneous Fistula After Total Laryngectomy

TypeinterventionalSponsorMansoura UniversityRan2024 to 2025Enrolled50ConditionsMalignant Tumor of the LarynxArmsTotal laryngectomy
3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 2 syntheses or guidelines pooled it, 91 citations in OpenAlex.

  1. The impact of immunonutrition in head and neck cancer surgery: a systematic review with meta-analysis.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2025
    Pooled it
  2. Pooled it
  3. [Comparison of pharyngocutaneous fistula after total laryngectomy with thyroid gland flap and traditional strap muscle].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2024
    Trial
  4. A comparison of the Thunderbeat and standard electrocautery devices in head and neck surgery: a prospective randomized controlled trial.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021
    Trial
  5. A clinically interpretable model for predicting pharyngocutaneous fistula after total laryngectomy.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
  6. Review
  7. Article
  8. Association of preoperative hemoglobin levels with the risk of pharyngocutaneous fistula after surgery for laryngeal and hypopharyngeal squamous cell carcinoma.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
  9. Article
  10. Risk factors for postoperative pharyngocutaneous fistula after total laryngectomy.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025
    Article
  11. Evaluation of research methodology generation by large language models in laryngology: a comparative analysis of ChatGPT-4.0 and Gemini 1.5 flash.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025
    Article
  12. Reconstruction of the Pharyngocutaneous Fistula After Laryngectomy with Full-Thickness Skin Graft and Pectoralis Major Myocutaneous Flap.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2025
    Article
  13. Article
  14. Results of Platelet-Rich Fibrin Application in Pharyngeal Reconstruction After a Total Laryngectomy.Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery · 2025
    Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Incidence and Management of Pharyngo Cutaneous Fistula Following Total Laryngectomy - A Single Institutional 10 Years Experience.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024
    Article
  20. Mapping the risk factors, pathogens, and antibiotic of pharyngocutaneous fistula in patients after neck open surgery.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Maohua Wang *Department of Otolaryngology, Head and Neck Surgery, XiangYa School of Medicine, Central South University, Changsha, 410000, People's Republic of China.
Youfang Xun *Department of Otolaryngology, Head and Neck Surgery, XiangYa School of Medicine, Central South University, Changsha, 410000, People's Republic of China.
Kaijian WangDepartment of Otolaryngology, Head and Neck Surgery, Drum Tower Clinical Medical College, Nanjing Medical University, Nanjing, 210008, People's Republic of China.
Ling LuDepartment of Otolaryngology, Head and Neck Surgery, Drum Tower Clinical Medical College, Nanjing Medical University, Nanjing, 210008, People's Republic of China.
Aimin YuDepartment of Otolaryngology, Head and Neck Surgery, Clinical Medical College of Yangzhou University, Yangzhou, 225001, People's Republic of China.
Bing GuanDepartment of Otolaryngology, Head and Neck Surgery, Clinical Medical College of Yangzhou University, Yangzhou, 225001, People's Republic of China. aliceguan0685@sina.com.ORCID http://orcid.org/0000-0002-9988-0743
Chenjie YuDepartment of Otolaryngology, Head and Neck Surgery, Drum Tower Clinical Medical College, Nanjing Medical University, Nanjing, 210008, People's Republic of China. Entphd@163.com.
Nanjing Drum Tower Hospital · CNCentral South University · CNYangzhou University · CN

Funding

Nanjing Medical Science and Technique Development Foundation QRX17051The Project of Invigorating Health Care through Science, Technology and Education ZDXKB2016015
6 · The paper itself

Abstract

objectiveThe purpose of this study was to systematically evaluate the risk factors of pharyngocutaneous fistula (PCF) after total laryngectomy.

methodsWe systematically searched Pubmed, Web of Science, Cochrane Library, and Embase databases and included the literature according to the inclusion and exclusion criteria.

resultsA total of 52 studies with 8605 patients were included in the meta-analysis. The total incidence of PCF was 21% (1808/8605). Meta-analysis results indicated that age (OR = 1.29, 95% CI 1.06-1.58, P = 0.01), smoking (OR = 1.62, 95% CI 1.27-2.07, P < 0.01), COPD (chronic obstructive pulmonary disease) (OR = 1.62, 95% CI 1.19-2.22, P < 0.01), CAD (coronary atherosclerotic heart disease) (OR = 1.82, 95% CI 1.36-2.45, P < 0.01), T-stage (OR = 0.81, 95% CI 0.67-0.98, P = 0.03), previous radiotherapy (OR = 2.41, 95% CI 2.00-2.90, P < 0.01), preoperative albumin (OR = 2.95, 95% CI 1.47-5.91, P < 0.01), preoperative hemoglobin (OR = 1.97, 95% CI 1.28-3.03, P < 0.01), tumor site (OR = 0.28, 95% CI 0.22-0.36, P < 0.01), and treatment method (OR = 1.85, 95% CI 1.44-2.38, P < 0.01) were risk factors associated with PCF.

conclusionsIn our study, age, smoking, COPD, CAD, T-stage, previous radiotherapy, preoperative albumin, preoperative hemoglobin, tumor site, and treatment method were risk factors of PCF.

Indexed as

Cutaneous FistulaHumansHypopharyngeal NeoplasmsLaryngeal NeoplasmsLaryngectomyPharyngeal DiseasesRetrospective StudiesRisk FactorsLaryngeal cancerMeta-analysisPharyngocutaneous fistulaRisk factorTotal laryngectomy

Identifiers

PMID31712878
OpenAlexW2985825453

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.