Evidence map›Paper›PMID 31712782›Full record

ReviewNature reviews. Neuroscience2019

An integrative framework for perceptual disturbances in psychosis.

Guillermo Horga, Anissa Abi-Dargham

Erratum issuedAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 103 citations in OpenAlex.

  1. Article
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  3. The hippocampus as a generative model.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026
    Review
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  13. Science advances · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Guillermo HorgaDeparment of Psychiatry, Columbia University, and New York State Psychiatric Institute, New York, NY, USA. HorgaG@nyspi.columbia.edu.
Anissa Abi-DarghamDepartment of Psychiatry, Stony Brook University, Stony Brook, NY, USA. anissa.abi-dargham@stonybrookmedicine.edu.ORCID http://orcid.org/0000-0002-5039-5069
New York Psychoanalytic Society and Institute · USStony Brook Medicine · US

Funding

Deficient Belief Updating as a Convergent Computational Mechanism of PsychosisR01MH114965 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI HORGA, GUILLERMO · 2018 to 2022
$3.6M
Neurobiological correlates of auditory processing in health and disease: an RDoC studyR01MH109635 · NIMH · STATE UNIVERSITY NEW YORK STONY BROOK · PI ABI-DARGHAM, ANISSA · 2016 to 2020
$3.5M
Individualized risk prediction in persons at clinical high-risk for psychosis using neuromelanin-sensitive MRI.R01MH117323 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI HORGA, GUILLERMO · 2018 to 2022
$3.3M
NIMH NIH HHS R01 MH109635NIMH NIH HHS R01 MH114965NIMH NIH HHS R01 MH117323
6 · The paper itself

Abstract

Perceptual disturbances in psychosis, such as auditory verbal hallucinations, are associated with increased baseline activity in the associative auditory cortex and increased dopamine transmission in the associative striatum. Perceptual disturbances are also associated with perceptual biases that suggest increased reliance on prior expectations. We review theoretical models of perceptual inference and key supporting physiological evidence, as well as the anatomy of associative cortico-striatal loops that may be relevant to auditory perceptual inference. Integrating recent findings, we outline a working framework that bridges neurobiology and the phenomenology of perceptual disturbances via theoretical models of perceptual inference.

Indexed as

Cerebral CortexCorpus StriatumDopamineHallucinationsHumansNerve NetPsychotic DisordersDopamine

Identifiers

PMID31712782
OpenAlexW2985021038

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.