Evidence map›Paper›PMID 31712781›Full record

ReviewNature reviews. Neuroscience2019

B cells in autoimmune and neurodegenerative central nervous system diseases.

Joseph J Sabatino, Anne-Katrin Pröbstel, Scott S Zamvil

Erratum issuedAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 214 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
214citing papers in PubMed, 6 pooled it
23.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

214 citing papers in PubMed, 6 syntheses or guidelines pooled it, 332 citations in OpenAlex.

  1. Rituximab for people with multiple sclerosis.The Cochrane database of systematic reviews · 2025
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Rituximab for people with multiple sclerosis.The Cochrane database of systematic reviews · 2021
    Pooled it
  7. Trial
  8. Article
  9. Article
  10. Article
  11. Review
  12. Lecanemab treatment improves B cell subpopulation immune homeostasis in patients with Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  13. Review
  14. Article
  15. Review
  16. Observational
  17. Article
  18. Review
  19. Review
  20. Article

154 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

Joseph J Sabatino *Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Anne-Katrin Pröbstel *Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-7748-1872
Scott S ZamvilDepartment of Neurology, University of California, San Francisco, San Francisco, CA, USA. zamvil@ucsf.neuroimmunol.org.ORCID http://orcid.org/0000-0003-2720-9915
University of California, San Francisco · US

Funding

Influence of NMO gut microbiota on CNS autoantigen-specific T cell responsesR21NS108159 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ZAMVIL, SCOTT S · 2018 to 2019
$451k
Single cell RNA-Seq and clonal analysis of CD8+ T cells in MSR21AI142186 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ZAMVIL, SCOTT S · 2019 to 2020
$443k
NIAID NIH HHS R21 AI142186NINDS NIH HHS R21 NS108159
6 · The paper itself

Abstract

B cells are essential components of the adaptive immune system and have important roles in the pathogenesis of several central nervous system (CNS) diseases. Besides producing antibodies, B cells perform other functions, including antigen presentation to T cells, production of proinflammatory cytokines and secretion of anti-inflammatory cytokines that limit immune responses. B cells can contribute to CNS disease either through their actions in the periphery (meaning that they have an 'outside-in' effect on CNS immunopathology) or following their compartmentalization within the CNS. The success of B cell-depleting therapy in patients with multiple sclerosis and CNS diseases with an autoantibody component, such as neuromyelitis optica spectrum disorder and autoimmune encephalitides, has underscored the role of B cells in both cellular and humoral-mediated CNS conditions. Emerging evidence suggests B cells also contribute to the pathogenesis of neurodegenerative diseases, including Alzheimer disease and Parkinson disease. Advancing our understanding of the role of B cells in neuroinflammatory and neurodegenerative diseases could lead to novel therapeutic approaches.

Indexed as

Adaptive ImmunityAnimalsAutoimmune DiseasesB-LymphocytesCentral Nervous System DiseasesHumansImmunosuppressive AgentsNeurodegenerative DiseasesImmunosuppressive Agents

Identifiers

PMID31712781
OpenAlexW2985088294

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.