ArticleNature neuroscience2019
Dynamic remodeling of a basolateral-to-central amygdala glutamatergic circuit across fear states.
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Article in Nature neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37citing papers in PubMed
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Who cites it
37 citing papers in PubMed.
- Cannabinoid modulation of central amygdala population dynamics during threat investigation.Nature communications · 2026Article
- A ventral hippocampus-basolateral amygdala circuit regulates the unconditioned stimulus retrieval-induced reconsolidation of remote fear memory.Journal of advanced research · 2026Article
- Reduced mediodorsal thalamus activity underlies aberrant belief dynamics in a genetic mouse model of schizophrenia.Nature neuroscience · 2026Article
- Corticotropin-Releasing Factor and Somatostatin Neurons in the Central Amygdala Mediate Dynamic Defensive Behaviors during Fear Extinction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- A Non-Mitophagy Activity of BNIP3L/NIX in Amygdala Glutamatergic Neurons is Essential for Contextual Fear Memory Formation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Stress History Modulates Corticotropin-Releasing Factor Neurons to Establish Resilience.Biological psychiatry global open science · 2026Article
- Chemogenetic modulation of CRF neurons in the BNST compensates for phenotypic behavioral differences in fear extinction learning of 5-HT2C receptor mutant mice.Translational psychiatry · 2026Article
- Parvalbumin interneurons gate amygdala excitability and response to chronic stress via kainate receptor-driven tonic GABAMolecular psychiatry · 2025Article
- How Fear Memory is Updated: From Reconsolidation to Extinction?Neuroscience bulletin · 2025Review
- Persistent Threat Avoidance Following Negative Reinforcement Is Not Associated with Elevated State Anxiety.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- PTEN in somatostatin neurons regulates fear and anxiety and is required for inhibitory synaptic connectivity within central amygdala.Frontiers in cellular neuroscience · 2025Article
- Neuronal excitation-inhibition imbalance in the basolateral amygdala is involved in propofol-mediated enhancement of fear memory.Communications biology · 2024Article
- Cells and circuits for amygdala neuroplasticity in the transition to chronic pain.Cell reports · 2024Article
- Central amygdala CRF+ neurons promote heightened threat reactivity following early life adversity in mice.Nature communications · 2024Article
- MPP2 interacts with SK2 to rescue the excitability of glutamatergic neurons in the BLA and facilitate the extinction of conditioned fear in mice.CNS neuroscience & therapeutics · 2024Article
- Opioidergic tuning of social attachment: reciprocal relationship between social deprivation and opioid abuse.Frontiers in neuroanatomy · 2024Review
- From aversive associations to defensive programs: experience-dependent synaptic modifications in the central amygdala.Trends in neurosciences · 2023Review
- Distinct populations of corticotropin-releasing factor (CRF) neurons mediate divergent yet complementary defensive behaviors in response to a threat.Neuropharmacology · 2023Review
- Article
- The basolateral amygdala to posterior insular cortex tract is necessary for social interaction with stressed juvenile rats.Behavioural brain research · 2022Article
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Authors and funding
9 authors.
Nolan D HartleyDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0003-4340-3478
Andrew D GauldenDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
Rita BáldiDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
Nathan D WintersDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
Gregory J SalimandoVanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA.
Luis Eduardo Rosas-VidalDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
Alexis JamesonDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
Danny G WinderDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
Sachin PatelDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA. sachin.patel@vanderbilt.edu.ORCID http://orcid.org/0000-0001-8052-520X
Funding
2-Arachidonoylglycerol signaling in anxiety, depression, and stress adaptationR01MH107435 · NIMH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PATEL, SACHIN · 2016 to 2025
$5.0MSex Dependent Recruitment of PKCdelta Neurons by Stress: Administrative Supplement for Noradrenergic Regulation in the BNSTR01DA042475 · NIDA · VANDERBILT UNIVERSITY · PI WINDER, DANNY G. · 2016 to 2025
$4.0MAlcohol action on extended amygdala glutamate synapsesR37AA019455 · NIAAA · VANDERBILT UNIVERSITY · PI WINDER, DANNY G. · 2015 to 2024
$3.9MEndocannabinoid Mechanisms in the Pathophysiology of Alcohol Use DisordersR01AA026186 · NIAAA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Sachin Patel · 2017 to 2026
$3.5MAlcohol action on extended amygdala glutamate synapsesR01AA019455 · NIAAA · VANDERBILT UNIVERSITY · PI WINDER, DANNY G. · 2010 to 2014
$1.8MAfferent-specific Endocannabinoid Signaling in the Central AmygdalaR21MH103515 · NIMH · VANDERBILT UNIVERSITY · PI PATEL, SACHIN · 2014 to 2015
$412kThe role of CRF neurons in the central amygdala on the expression of fear and related anxiety behaviorsF31MH111103 · NIMH · VANDERBILT UNIVERSITY · PI HARTLEY, NOLAN D · 2016 to 2017
$57kNIAAA NIH HHS R01 AA019455NIAAA NIH HHS R01 AA026186NIAAA NIH HHS R37 AA019455NIDA NIH HHS R01 DA042475NIMH NIH HHS F31 MH111103NIMH NIH HHS R01 MH107435NIMH NIH HHS R21 MH103515
Abstract
Acquisition and extinction of learned fear responses utilize conserved but flexible neural circuits. Here we show that acquisition of conditioned freezing behavior is associated with dynamic remodeling of relative excitatory drive from the basolateral amygdala (BLA) away from corticotropin releasing factor-expressing (CRF
Indexed as
AnimalsBasolateral Nuclear ComplexCentral Amygdaloid NucleusConditioning, ClassicalCorticotropin-Releasing HormoneExcitatory Postsynaptic PotentialsExtinction, PsychologicalFearFreezing Reaction, CatalepticGlutamic AcidMice, TransgenicNeural PathwaysSomatostatinCorticotropin-Releasing HormoneGlutamic AcidSomatostatin
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.