ArticleThe ISME journal2020
Microbial succession during wheat bran fermentation and colonisation by human faecal microbiota as a result of niche diversification.
Article in The ISME journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 51 citations in OpenAlex.
- Microbial enterotypes beyond genus level:Gut microbes · 2020Trial
- From gut dysbiosis to eubiosis: understanding microbiome recovery as an ecological process.Gut microbes · 2026Review
- In vitro study on the role of endoxylanase-driven fibre solubilisation and fibre particle size in improving fibre fermentation in broilers.Poultry science · 2026Article
- Resistance of Bamboo Fibers to Gastrointestinal Digestion and Their Nutrient-Dependent Fermentation by Human Gut Microbiota.Foods (Basel, Switzerland) · 2026Article
- Extensive particle size reduction of wheat bran increases the broiler's caecal fermentative capacity, but not bran fermentability ex vivo.Poultry science · 2026Article
- Microbiota shape the colon epithelium controlling inter-crypt absorptive goblet cells via butyrate-GP R109A signalling.Gut microbes · 2025Article
- Non-invasive VOCs detection to monitor the gut microbiota metabolism in-vitro.Scientific reports · 2024Article
- Epilactose as a Promising Butyrate-Promoter Prebiotic via Microbiota Modulation.Life (Basel, Switzerland) · 2024Article
- Interplay between particle size and microbial ecology in the gut microbiome.bioRxiv : the preprint server for biology · 2024Article
- Interplay between particle size and microbial ecology in the gut microbiome.The ISME journal · 2024Article
- Sugar lowering in fermented apple-pear juice orchestrates a promising metabolic answer in the gut microbiome and intestinal integrity.Current research in food science · 2024Article
- The curious case ofGut microbes · 2023Review
- Buckwheat (International journal of molecular sciences · 2023Article
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- Gut Microbiota Patterns Predicting Long-Term Weight Loss Success in Individuals with Obesity Undergoing Nonsurgical Therapy.Nutrients · 2022Article
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- Understanding the Xylooligosaccharides Utilization Mechanism of Lactobacillus brevis and Bifidobacterium adolescentis: Proteins Involved and Their Conformational Stabilities for Effectual Binding.Molecular biotechnology · 2022Article
- Diets, nutrients, genes and the microbiome: recent advances in personalised nutrition.The British journal of nutrition · 2021Review
- Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The human gut can be viewed as a flow-through system with a short residence time, a high turnover rate and a spatial gradient of physiological conditions. As a consequence, the gut microbiota is exposed to highly fluctuating environmental determinants presented by the host and diet. Here, we assessed the fermentation and colonisation of insoluble wheat bran by faecal microbiota of three individuals at an unprecedented sampling intensity. Time-resolved 16S rRNA gene amplicon sequencing, revealed a dynamic microbial community, characterised by abrupt shifts in composition, delimiting states with a more constant community, giving rise to a succession of bacterial taxa alternately dominating the community over a 72 h timespan. Early stages were dominated by Enterobacteriaceae and Fusobacterium species, growing on the carbohydrate-low, protein rich medium to which wheat bran was supplemented. The onset of wheat bran fermentation, marked by a spike in short chain fatty acid production with an increasing butyrate proportion and an increased endo-1,4-β-xylanase activity, corresponded to donor-dependent proportional increases of Bacteroides ovatus/stercoris, Prevotella copri and Firmicutes species, which were strongly enriched in the bran-attached community. Literature and database searches provided novel insights into the metabolic and growth characteristics underlying the observed succession and colonisation, illustrating the potency of a time-resolved analysis to increase our understanding of gut microbiota dynamics upon dietary modulations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.