ArticleScientific reports2019
Identification and characterization of circular RNAs in Ganoderma lucidum.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Regulatory Manner and Role of Circular RNAs in the Microsporidian Invasion of Asian Honeybee.Animals : an open access journal from MDPI · 2026Article
- Species-specific circular RNA circDS-1 enhances adaptive evolution in Talaromyces marneffei through regulation of dimorphic transition.PLoS genetics · 2025Article
- Discovering the hidden function in fungal genomes.Nature communications · 2024Review
- Identification of circular RNAs of Cannabis sativa L. potentially involved in the biosynthesis of cannabinoids.Planta · 2023Article
- Cost-Effective Transcriptome-Wide Profiling of Circular RNAs by the Improved-tdMDA-NGS Method.Frontiers in molecular biosciences · 2022Article
- Expression and Secretion of Circular RNAs in the Parasitic Nematode,Frontiers in genetics · 2022Article
- Article
- Efficient expression of heterologous genes by the introduction of the endogenous glyceraldehyde-3-phosphate dehydrogenase gene intron 1 in Ganoderma lucidum.Microbial cell factories · 2021Article
- Genome-Wide Identification of Circular RNAs Potentially Involved in the Biosynthesis of Secondary Metabolites inFrontiers in genetics · 2021Article
- Circular RNAs Interaction with MiRNAs: Emerging Roles in Breast Cancer.International journal of medical sciences · 2021Review
- Identification of Circular RNA Expression Profiles in White Adipocytes and Their Roles in Adipogenesis.Frontiers in physiology · 2021Article
- Generation of Transgenic Rice Expressing CircRNA and Its Functional Characterization.Methods in molecular biology (Clifton, N.J.) · 2021Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Circular RNAs (circRNAs) play important roles in animals, plants, and fungi. However, no circRNAs have been reported in Ganoderma lucidum. Here, we carried out a genome-wide identification of the circRNAs in G.lucidum using RNA-Seq data, and analyzed their features. In total, 250 and 2193 circRNAs were identified from strand-specific RNA-seq data generated from the polyA(-) and polyA(-)/RNase R-treated libraries, respectively. Six of 131 (4.58%) predicted circRNAs were experimentally confirmed. Across three developmental stages, 731 exonic circRNAs (back spliced read counts ≥ 5) and their parent genes were further analyzed. CircRNAs were preferred originating from exons with flanking introns, and the lengths of the flanking intron were longer than those of the control introns. A total of 200 circRNAs were differentially expressed across the three developmental stages of G. lucidum. The expression profiles of 119 (16.3%) exonic circRNAs and their parent genes showed significant positive correlations (r ≥ 0.9, q < 0.01), whereas 226 (30.9%) exonic circRNAs and their parent genes exhibited significant negative correlations (r ≤ -0.9, q < 0.01), in which 53 parent genes are potentially involved in the transcriptional regulation, polysaccharide biosynthesis etc. Our results indicated that circRNAs are present in G. lucidum, with potentially important regulatory roles.
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