ArticleScientific reports2019
Pseudomonas aeruginosa quorum sensing inhibition by clinical isolate Delftia tsuruhatensis 11304: involvement of N-octadecanoylhomoserine lactones.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Targeting biofilm and virulence inMicrobiology spectrum · 2026Article
- Ecological dynamics of three persistent opportunistic pathogens in hospital sinks and their potential antagonistic bacteria.mSystems · 2026Article
- Anti-QS Strategies AgainstMicroorganisms · 2025Review
- Leishmania sand fly-transmission is disrupted by Delftia tsuruhatensis TC1 bacteria.Nature communications · 2025Article
- Combatting biofilm-mediated infections in clinical settings by targeting quorum sensing.Cell surface (Amsterdam, Netherlands) · 2024Review
- Article
- Theophylline as a quorum sensing and biofilm inhibitor in Pseudomonas aeruginosa and Chromobacterium violaceum.International microbiology : the official journal of the Spanish Society for Microbiology · 2024Article
- Synthesis and study of antibiofilm and antivirulence properties of flavonol analogues generated by palladium catalyzed ligand free Suzuki-Miyaura coupling againstRSC advances · 2024Article
- Evaluation of novel compounds as anti-bacterial or anti-virulence agents.Frontiers in cellular and infection microbiology · 2024Review
- Article
- Synthesis of Antimicrobial Gallium Nanoparticles Using the Hot Injection Method.ACS materials Au · 2023Article
- Genomic analysis of multidrug-resistantFrontiers in microbiology · 2023Article
- A Brominated Furanone InhibitsBiomedicines · 2022Article
- Quorum Sensing Inhibitory and Quenching Activity ofACS omega · 2022Article
- Dynamics of the protein search for targets on DNA in quorum-sensing cells.Biophysical journal · 2022Article
- Optimization of cultural conditions for enhancement of anti-quorum sensing potential in the probiotic strain3 Biotech · 2022Article
- Pan-Genome Analysis of Delftia tsuruhatensis Reveals Important Traits Concerning the Genetic Diversity, Pathogenicity, and Biotechnological Properties of the Species.Microbiology spectrum · 2022Article
- Polyphenols as Inhibitors of Antibiotic Resistant Bacteria-Mechanisms Underlying Rutin Interference with Bacterial Virulence.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Inhibition of the Quorum Sensing System, Elastase Production and Biofilm Formation inMolecules (Basel, Switzerland) · 2022Article
- Article
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10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pseudomonas aeruginosa is one of the most common opportunistic pathogens that use quorum sensing (QS) system to regulate virulence factors expression and biofilm development. Delftia sp. 11304 was selected among 663 Gram-negative clinical isolates based on its QS inhibitory activity against P. aeruginosa MMA83 clinical isolate. Whole genome sequencing identified this isolate as D. tsuruhatensis and revealed genetic armamentarium of virulence factors and antibiotic resistance determinants. Ethyl acetate extract of D. tsuruhatensis 11304 culture supernatant (QSI extract) prevented biofilm formation of P. aeruginosa MMA83, but was unable to cause biofilm decomposition. QSI extract showed a synergistic effect in combination with meropenem and gentamycin, against P. aeruginosa MMA83. A dose-dependent reduction of the virulence factors: elastase, rhamnolipid and pyocyanin production by P. aeruginosa MMA83 and significant downregulation of lasI, lasR, rhlI, rhlR, pqs and mvfR expression were observed. Matrix-assisted Laser Desorption Ionization (MALDI) mass spectrometry of D. tsuruhatensis 11304 QSI extract revealed the presence of N-acyl homoserine lactones (AHL) with chain lengths of C12 to C18. The main ion peak was identified as N-octadecanoylhomoserine lactone (C
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