ArticleMolecular psychiatry2021
Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders.
Article in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Genome-wide association meta-analyses of drug-resistant epilepsy.EBioMedicine · 2025Pooled it
- Genetic factors influencing a neurobiological substrate for psychiatric disorders.Translational psychiatry · 2021Pooled it
- Molecular and Neuroimaging Correlates of Bipolar Disorder: Linking Inflammation, Mitochondria, and Brain Circuitry.International journal of molecular sciences · 2026Review
- Polygenic scores for psychiatric traits mediate the impact of multigenerational history for depression on offspring psychopathology.Molecular psychiatry · 2026Article
- Shared Genetic Architecture Among Severe Mental Disorders: A System Biology Approach Based on Protein-Protein Interaction.Brain and behavior · 2025Article
- The relationships between impulsivity and mood in bipolar disorder: An ecological momentary assessment study.PloS one · 2025Article
- Factor analysis of lifetime psychopathology and its brain morphometric and genetic correlates in a transdiagnostic sample.Translational psychiatry · 2024Article
- Polygenic risk for suicide attempt is associated with lifetime suicide attempt in US soldiers independent of parental risk.Journal of affective disorders · 2024Article
- Association of polygenic risk for bipolar disorder with grey matter structure and white matter integrity in youth.Translational psychiatry · 2023Article
- The interplay of family history of depression and early trauma: associations with lifetime and current depression in the German national cohort (NAKO).Frontiers in epidemiology · 2023Article
- Article
- Examining the source of increased bipolar disorder and major depressive disorder common risk variation burden in multiplex schizophrenia families.Schizophrenia (Heidelberg, Germany) · 2022Article
- Evaluating the role of common risk variation in the recurrence risk of schizophrenia in multiplex schizophrenia families.Translational psychiatry · 2022Article
- Genomic and neuroimaging approaches to bipolar disorder.BJPsych open · 2022Review
- Identifying transdiagnostic biological subtypes across schizophrenia, bipolar disorder, and major depressive disorder based on lipidomics profiles.Frontiers in cell and developmental biology · 2022Article
- Elevated common variant genetic risk for tourette syndrome in a densely-affected pedigree.Molecular psychiatry · 2021Article
- Polygenic risk for major depression is associated with lifetime suicide attempt in US soldiers independent of personal and parental history of major depression.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2021Article
- The conserved ASTN2/BRINP1 locus at 9q33.1-33.2 is associated with major psychiatric disorders in a large pedigree from Southern Spain.Scientific reports · 2021Article
- Treatment- and population-specific genetic risk factors for anti-drug antibodies against interferon-beta: a GWAS.BMC medicine · 2020Article
- Article
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Authors and funding
32 authors at 20 institutions in 24 countries.
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Abstract
Multiplex families with a high prevalence of a psychiatric disorder are often examined to identify rare genetic variants with large effect sizes. In the present study, we analysed whether the risk for bipolar disorder (BD) in BD multiplex families is influenced by common genetic variants. Furthermore, we investigated whether this risk is conferred mainly by BD-specific risk variants or by variants also associated with the susceptibility to schizophrenia or major depression. In total, 395 individuals from 33 Andalusian BD multiplex families (166 BD, 78 major depressive disorder, 151 unaffected) as well as 438 subjects from an independent, BD case/control cohort (161 unrelated BD, 277 unrelated controls) were analysed. Polygenic risk scores (PRS) for BD, schizophrenia (SCZ), and major depression were calculated and compared between the cohorts. Both the familial BD cases and unaffected family members had higher PRS for all three psychiatric disorders than the independent controls, with BD and SCZ being significant after correction for multiple testing, suggesting a high baseline risk for several psychiatric disorders in the families. Moreover, familial BD cases showed significantly higher BD PRS than unaffected family members and unrelated BD cases. A plausible hypothesis is that, in multiplex families with a general increase in risk for psychiatric disease, BD development is attributable to a high burden of common variants that confer a specific risk for BD. The present analyses demonstrated that common genetic risk variants for psychiatric disorders are likely to contribute to the high incidence of affective psychiatric disorders in the multiplex families. However, the PRS explained only part of the observed phenotypic variance, and rare variants might have also contributed to disease development.
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