SynthesisMolecular psychiatry2021
Genome-wide association study of panic disorder reveals genetic overlap with neuroticism and depression.
Abstract readMeta-Analysis
In one paragraph
Synthesis in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 4 pooled it
–field-weighted citation impact
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
75 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling.Nature genetics · 2026Pooled it
- The Genetic Architecture of the Human Corpus Callosum and its Subregions.Nature communications · 2025Pooled it
- The impact of assortative mating, participation bias and socioeconomic status on the polygenic risk of behavioural and psychiatric traits.Nature human behaviour · 2024Pooled it
- Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications.Nature communications · 2024Pooled it
- Convex approaches to isolate the shared and distinct genetic components of complex traits.Bioinformatics (Oxford, England) · 2026Article
- Exploring the shared genetic architecture and causal relationship between childhood maltreatment and psychiatric disorders.Molecular psychiatry · 2026Article
- Genomic dimensions deconstruct the clinical heterogeneity of bipolar disorder.Research square · 2026Article
- Long-Term Ambient Benzene Exposure and Brain Disorders Among Urban Adults: Effect Modification by Genetic Susceptibility and Potential Mediation by Plasma Proteins.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Transcriptional Response to Chronic Long-Access Fentanyl Self-Administration in Rat Habenula and Amygdala.Addiction biology · 2026Article
- Genome-wide genetic overlap between fear-based disorders and generalised anxiety disorder.Molecular psychiatry · 2026Article
- Mapping the genetic architecture of human cortical expansion and its links to neuropsychiatric disorders.bioRxiv : the preprint server for biology · 2026Article
- The causal relationships between childhood-onset asthma and major mental disorders: an MR study.European archives of psychiatry and clinical neuroscience · 2026Article
- A genetic atlas of relationships between circulating metabolites and liability to psychiatric conditions.Molecular psychiatry · 2026Article
- Spatiotemporal brain transcriptomics reveal risk gene hot-spots in major neuropsychiatric disorders.Communications biology · 2026Article
- Rare protein-disrupting variants inmedRxiv : the preprint server for health sciences · 2026Article
- Molecular dynamics of Brodmann Area 22 in development and autism.bioRxiv : the preprint server for biology · 2026Article
- Timing of Exposure to Parental Depression From Pregnancy to Young Adulthood and Mental Health in Adult Offspring.JAMA network open · 2026Article
- Shared Pathogenic Pathways Between REM Sleep Behavior Disorder and Neurodegenerative and Psychiatric Disorders.medRxiv : the preprint server for health sciences · 2026Article
- Multi-omics Differential Inference for Functional Interpretation (MoDIFI): A Statistical Framework to Prioritize Cell Lines for Neurodevelopmental Variants.bioRxiv : the preprint server for biology · 2026Article
- Disturbances of paraventricular thalamic nucleus neurons in bipolar disorder revealed by single-nucleus analysis.Nature communications · 2026Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
75 authors.
Andreas J Forstner *Centre for Human Genetics, University of Marburg, Marburg, Germany.
Swapnil Awasthi *Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany.
Christiane Wolf *Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University of Würzburg, Würzburg, Germany.
Eduard MaronDepartment of Psychiatry, University of Tartu, Tartu, Estonia.
Angelika ErhardtDepartment of Translational Research in Psychiatry, Max-Planck-Institute of Psychiatry, Munich, Germany.
Darina CzamaraDepartment of Translational Research in Psychiatry, Max-Planck-Institute of Psychiatry, Munich, Germany.ORCID http://orcid.org/0000-0001-7381-904X
Elias ErikssonDepartment of Pharmacology, Institute of Neuroscience, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Catharina LavebrattDepartment of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-4987-2718
Christer AllgulanderKarolinska Institutet, Stockholm, Sweden.
Nina FriedrichInstitute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.
Jessica BeckerInstitute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.
Julian HeckerDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Stefanie RambauDepartment of Psychosomatic Medicine and Psychotherapy, University of Bonn, Bonn, Germany.
Rupert ConradDepartment of Psychosomatic Medicine and Psychotherapy, University of Bonn, Bonn, Germany.
Franziska GeiserDepartment of Psychosomatic Medicine and Psychotherapy, University of Bonn, Bonn, Germany.
Francis J McMahonHuman Genetics Branch, National Institute of Mental Health Intramural Research Program, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-9469-305X
Susanne MoebusCentre for Urban Epidemiology, IMIBE, University Duisburg-Essen, Essen, Germany.
Timo HessCentre for Human Genetics, University of Marburg, Marburg, Germany.
Benedikt C BuerfentCentre for Human Genetics, University of Marburg, Marburg, Germany.
Per HoffmannInstitute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.
Stefan HermsInstitute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0002-2786-8200
Stefanie Heilmann-HeimbachInstitute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.
Ingrid KockumDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-0867-4726
Tomas OlssonDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Lars AlfredssonInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Heike WeberDepartment of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University of Würzburg, Würzburg, Germany.ORCID http://orcid.org/0000-0002-9421-1292
Georg W AlpersClinical and Biological Psychology, School of Social Sciences and Otto-Selz-Institute, University of Mannheim, Mannheim, Germany.
Volker AroltDepartment of Psychiatry and Psychotherapy, University of Münster, Münster, Germany.
Lydia FehmDepartment of Psychology, Humboldt-University Berlin, Berlin, Germany.
Thomas FydrichDepartment of Psychology, Humboldt-University Berlin, Berlin, Germany.
Alexander L GerlachInstitute of Clinical Psychology and Psychotherapy, University of Cologne, Cologne, Germany.ORCID http://orcid.org/0000-0001-6794-5349
Alfons HammDepartment of Biological and Clinical Psychology, University of Greifswald, Greifswald, Germany.
Tilo KircherDepartment of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany.
Christiane A Pané-FarréDepartment of Biological and Clinical Psychology, University of Greifswald, Greifswald, Germany.
Paul PauliDepartment of Psychology and Center of Mental Health, University of Würzburg, Würzburg, Germany.ORCID http://orcid.org/0000-0003-0692-6720
Winfried RiefPsychologie, Philipps- Universität Marburg, Marburg, Germany.
Andreas StröhleDepartment of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Jens PlagDepartment of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Thomas LangIPP Bremen GmbH, Bremen, Germany.
Hans-Ulrich WittchenDepartment of Psychology, Institute of Clinical Psychology and Psychotherapy, Technische Universität Dresden, Dresden, Germany.
Manuel MattheisenDepartment of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University of Würzburg, Würzburg, Germany.
Sandra MeierDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Andres MetspaluInstitute of Genomics and Estonian Genome Center, University of Tartu, Tartu, Estonia.
Katharina DomschkeDepartment of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Andreas ReifDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt am Main, Frankfurt am Main, Germany.ORCID http://orcid.org/0000-0002-0992-634X
Iiris HovattaResearch Program of Molecular and Integrative Biosciences, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-5990-7892
Nils LindeforsCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Stockholm County Council, Huddinge, Sweden.
Evelyn AnderssonCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Stockholm County Council, Huddinge, Sweden.
Martin SchallingDepartment of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
Hamdi MbarekDepartment of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-1108-0371
Yuri MilaneschiDepartment of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit/GGZ inGeest, Amsterdam, The Netherlands.
Eco J C de GeusDepartment of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Dorret I BoomsmaDepartment of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-7099-7972
Brenda W J H PenninxDepartment of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit/GGZ inGeest, Amsterdam, The Netherlands.
Thorgeir E ThorgeirssondeCODE Genetics / Amgen, Reykjavik, Iceland.
Stacy SteinbergdeCODE Genetics / Amgen, Reykjavik, Iceland.ORCID http://orcid.org/0000-0001-7726-5152
Kari StefanssondeCODE Genetics / Amgen, Reykjavik, Iceland.
Hreinn StefanssondeCODE Genetics / Amgen, Reykjavik, Iceland.ORCID http://orcid.org/0000-0002-9331-6666
Bertram Müller-MyhsokDepartment of Translational Research in Psychiatry, Max-Planck-Institute of Psychiatry, Munich, Germany.
Thomas Folkmann HansenDanish Headache Center, Department of Neurology, Rigshospitalet, Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-6703-7762
Anders D BørglumiPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Thomas WergeInstitute of Biological Psychiatry, MHC Sct. Hans, Mental Health Services Copenhagen, Roskilde, Denmark.
Preben Bo MortenseniPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Merete NordentoftiPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
David M HougaardiPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.ORCID http://orcid.org/0000-0001-5928-3517
Christina M HultmanDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Patrick F SullivanDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Markus M NöthenInstitute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.
David P D WoldbyeDepartment of Neuroscience, University of Copenhagen, Copenhagen, Denmark.
Ole MorsiPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Elisabeth B BinderDepartment of Translational Research in Psychiatry, Max-Planck-Institute of Psychiatry, Munich, Germany.ORCID http://orcid.org/0000-0001-7088-6618
Christian RückCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Stockholm County Council, Huddinge, Sweden.ORCID http://orcid.org/0000-0002-8742-0168
Stephan Ripke *Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany.
Jürgen Deckert *Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University of Würzburg, Würzburg, Germany.
Johannes Schumacher *Centre for Human Genetics, University of Marburg, Marburg, Germany. johannes.schumacher@uni-marburg.de.
Funding
NIMH Center Repository Supporting Stem Cell ResearchU24MH068457 · NIMH · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI BRZUSTOWICZ, LINDA M, KNOWLES, JAMES A · 2003 to 2024
$213.8MIdentification of Genes Involved in Major Mood DisordersZIAMH002843 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI MCMAHON, FRANCIS J · 2009 to 2025
$24.5MIntegration of Genomics & Transcriptomics in Normal Twins & Major DepressionRC2MH089951 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SULLIVAN, PATRICK F · 2009 to 2010
$6.5MGenomics of Developmental Trajectories in TwinsRC2MH089995 · NIMH · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI HUDZIAK, JAMES J. · 2009 to 2010
$3.8M5/7 Psychiatric Genomics Consortium: Finding actionable variationU01MH109514 · NIMH · CARDIFF UNIVERSITY · PI O'DONOVAN, MICHAEL · 2016 to 2020
$2.9MCollaborative Study of Genetics of Dizygotic TwinningR01HD042157 · NICHD · QUEENSLAND INSTITUTE OF MEDICAL RESEARCH · PI MONTGOMERY, GRANT W · 2002 to 2006
$2.0MNICHD NIH HHS R01 HD042157NIMH NIH HHS RC2 MH089951NIMH NIH HHS RC2 MH089995NIMH NIH HHS U01 MH109514NIMH NIH HHS U24 MH068457
Abstract
Panic disorder (PD) has a lifetime prevalence of 2-4% and heritability estimates of 40%. The contributory genetic variants remain largely unknown, with few and inconsistent loci having been reported. The present report describes the largest genome-wide association study (GWAS) of PD to date comprising genome-wide genotype data of 2248 clinically well-characterized PD patients and 7992 ethnically matched controls. The samples originated from four European countries (Denmark, Estonia, Germany, and Sweden). Standard GWAS quality control procedures were conducted on each individual dataset, and imputation was performed using the 1000 Genomes Project reference panel. A meta-analysis was then performed using the Ricopili pipeline. No genome-wide significant locus was identified. Leave-one-out analyses generated highly significant polygenic risk scores (PRS) (explained variance of up to 2.6%). Linkage disequilibrium (LD) score regression analysis of the GWAS data showed that the estimated heritability for PD was 28.0-34.2%. After correction for multiple testing, a significant genetic correlation was found between PD and major depressive disorder, depressive symptoms, and neuroticism. A total of 255 single-nucleotide polymorphisms (SNPs) with p < 1 × 10
Indexed as
Major Depressive DisorderNeuroticismPanic DisorderDenmarkDepressionEstoniaGenetic Predisposition to DiseaseGenome-Wide Association StudyGermanyHumansPolymorphism, Single NucleotideSweden
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