ArticleScientific reports2019
Oncogenes, tumor suppressor and differentiation genes represent the oldest human gene classes and evolve concurrently.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 26 citations in OpenAlex.
- Advance and challenge of DNA methylation as cancer biomarkers for risk stratification, screening and early detection.Journal of the National Cancer Center · 2025Article
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- Comparative study of the evolution of cancer gene duplications across fish.Evolutionary applications · 2022Article
- Mammalian tumor-like organs. 1. The role of tumor-like normal organs and atypical tumor organs in the evolution of development (carcino-evo-devo).Infectious agents and cancer · 2022Review
- DORGE: Discovery of Oncogenes and tumoR suppressor genes using Genetic and Epigenetic features.Science advances · 2020Article
- The Evolution of Human Cancer Gene Duplications across Mammals.Molecular biology and evolution · 2020Article
- The Role of Heritable Tumors in Evolution of Development: a New Theory of Carcino-evo-devo.Acta naturaeArticle
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Earlier we showed that human genome contains many evolutionarily young or novel genes with tumor-specific or tumor-predominant expression. We suggest calling such genes Tumor Specifically Expressed, Evolutionarily New (TSEEN) genes. In this paper we performed a study of the evolutionary ages of different classes of human genes, using homology searches in genomes of different taxa in human lineage. We discovered that different classes of human genes have different evolutionary ages and confirmed the existence of TSEEN gene classes. On the other hand, we found that oncogenes, tumor-suppressor genes and differentiation genes are among the oldest gene classes in humans and their evolution occurs concurrently. These findings confirm non-trivial predictions made by our hypothesis of the possible evolutionary role of hereditary tumors. The results may be important for better understanding of tumor biology. TSEEN genes may become the best tumor markers.
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