Evidence map›Paper›PMID 31712600›Full record

ArticleMucosal immunology2020

Single-cell RNA-sequencing identifies the developmental trajectory of C-Myc-dependent NK1.1

Jonas F Hummel, Patrice Zeis, Karolina Ebert, Jonas Fixemer, Philip Konrad, Christian Schachtrup, Sebastian J Arnold, Dominic Grün, Yakup Tanriver

Open access · hybridAbstract read
In one paragraph

Article in Mucosal immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Epigenetic Regulation of CD8European journal of immunology · 2025
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Human Thymic CD10International journal of molecular sciences · 2020
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Jonas F HummelInstitute of Medical Microbiology and Hygiene, Faculty of Medicine, University of Freiburg, 79104, Freiburg, Germany.
Patrice ZeisMax Planck Institute of Immunobiology and Epigenetics, 79108, Freiburg, Germany.
Karolina EbertInstitute of Medical Microbiology and Hygiene, Faculty of Medicine, University of Freiburg, 79104, Freiburg, Germany.
Jonas FixemerInstitute of Medical Microbiology and Hygiene, Faculty of Medicine, University of Freiburg, 79104, Freiburg, Germany.
Philip KonradInstitute of Medical Microbiology and Hygiene, Faculty of Medicine, University of Freiburg, 79104, Freiburg, Germany.
Christian SchachtrupInstitute of Anatomy and Cell Biology, Faculty of Medicine, University of Freiburg, 79104, Freiburg, Germany.
Sebastian J ArnoldInstitute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Freiburg, 79104, Freiburg, Germany.
Dominic GrünMax Planck Institute of Immunobiology and Epigenetics, 79108, Freiburg, Germany.
Yakup TanriverInstitute of Medical Microbiology and Hygiene, Faculty of Medicine, University of Freiburg, 79104, Freiburg, Germany. yakup.tanriver@uniklinik-freiburg.de.
University of Freiburg · DEInstitute of Medical Microbiology and Hygiene · DEMax Planck Institute of Immunobiology and Epigenetics · DEUniversity Medical Center Freiburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Natural intraepithelial lymphocytes (IELs) are thymus-derived adaptive immune cells, which are important contributors to intestinal immune homeostasis. Similar to other innate-like T cells, they are induced in the thymus through high-avidity interaction that would otherwise lead to clonal deletion in conventional CD4 and CD8 T cells. By applying single-cell RNA-sequencing (scRNA-seq) on a heterogeneous population of thymic CD4

Indexed as

AnimalsAntigens, LyCells, CulturedGene Expression RegulationImmunity, InnateInhibitor of Differentiation Protein 2Inhibitor of Differentiation ProteinsInterleukin-2 Receptor beta SubunitIntraepithelial LymphocytesMiceMice, Inbred C57BLMice, TransgenicNK Cell Lectin-Like Receptor Subfamily BPrecursor Cells, T-LymphoidProto-Oncogene Proteins c-mycSequence Analysis, RNAAntigens, LyIdb2 protein, mouseIdb3 protein, mouseInhibitor of Differentiation Protein 2Inhibitor of Differentiation ProteinsInterleukin-2 Receptor beta SubunitKlrb1c protein, mouseMyc protein, mouseNK Cell Lectin-Like Receptor Subfamily BProto-Oncogene Proteins c-mycT-bet Transcription FactorT-Box Domain Proteins

Identifiers

PMID31712600
PMCPMC7039806
OpenAlexW2983865223

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.