Evidence map›Paper›PMID 31712587›Full record

ArticleScientific reports2019

The Resistome, Mobilome, Virulome and Phylogenomics of Multidrug-Resistant Escherichia coli Clinical Isolates from Pretoria, South Africa.

Nontombi Marylucy Mbelle, Charles Feldman, John Osei Sekyere, Nontuthuko Excellent Maningi, Lesedi Modipane, Sabiha Yusuf Essack

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 76 citations in OpenAlex.

  1. Article
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  3. Article
  4. Review
  5. Article
  6. Article
  7. Genomic Insights of Antibiotic-ResistantAntibiotics (Basel, Switzerland) · 2025
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  8. Genomic insights into extended-spectrumJournal of medical microbiology · 2025
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  9. Article
  10. Observational
  11. Article
  12. Article
  13. Whole-Genome Sequencing of Human and PorcineAntibiotics (Basel, Switzerland) · 2024
    Article
  14. Article
  15. Article
  16. Antimicrobial resistance in food-associatedBioscience of microbiota, food and health · 2024
    Review
  17. Antimicrobial Resistance inAntibiotics (Basel, Switzerland) · 2023
    Article
  18. Genomic Analysis of Multidrug-ResistantTropical medicine and infectious disease · 2023
    Article
  19. Article
  20. Antimicrobial resistance genes ofAIMS microbiology · 2023
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Nontombi Marylucy MbelleDepartment of Medical Microbiology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
Charles FeldmanDepartment of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
John Osei SekyereDepartment of Medical Microbiology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa. jod14139@gmail.com.
Nontuthuko Excellent ManingiDepartment of Medical Microbiology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
Lesedi ModipaneDepartment of Medical Microbiology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
Sabiha Yusuf EssackAntimicrobial Research Unit, College of Health Sciences, University of KwaZulu/Natal, Durban, South Africa.
University of Pretoria · ZANational Health Laboratory Service · ZAUniversity of KwaZulu-Natal · ZAUniversity of the Witwatersrand · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antibiotic-resistant Escherichia coli is a common occurrence in food, clinical, community and environmental settings worldwide. The resistome, mobilome, virulome and phylogenomics of 20 multidrug resistant (MDR) clinical E. coli isolates collected in 2013 from Pretoria, South Africa, were characterised. The isolates were all extended-spectrum β-lactamase producers, harbouring CTX-M (n = 16; 80%), TEM-1B (n = 10; 50%) and OXA (n = 12, 60%) β-lactamases alongside genes mediating resistance to fluoroquinolones, aminoglycosides, tetracyclines etc. Most resistance determinants were found on contigs containing IncF plasmid replicons and bracketed by composite transposons (Tn3), diverse ISs and class 1 integrons (In13, In54, In369, and In467). Gene cassettes such as bla

Indexed as

Interspersed Repetitive SequencesPhylogenyAdolescentAdultAgedChildChild, PreschoolDrug Resistance, Multiple, BacterialEscherichia coliEscherichia coli InfectionsEscherichia coli ProteinsFemaleGenomic IslandsGenotypeHumansMaleEscherichia coli Proteins

Identifiers

PMID31712587
PMCPMC6848087
OpenAlexW2988010214

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.