ArticleScientific reports2019
A feedback loop of conditionally stable circuits drives the cell cycle from checkpoint to checkpoint.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Epitranscriptomics as a Candidate Universal Modulator of Dormancy Transitions.Ecology and evolution · 2026Review
- Low dimensionality of phenotypic space as an emergent property of coordinated teams in biological regulatory networks.iScience · 2025Article
- Canalizing kernel for cell fate determination.Briefings in bioinformatics · 2024Article
- A comprehensive review of computational cell cycle models in guiding cancer treatment strategies.NPJ systems biology and applications · 2024Review
- Decoding the principle of cell-fate determination for its reverse control.NPJ systems biology and applications · 2024Article
- A network-based modeling framework reveals the core signal transduction network underlying high carbon dioxide-induced stomatal closure in guard cells.PLoS biology · 2024Article
- Models of Cell Processes are Far from the Edge of Chaos.PRX life · 2023Article
- Computational analysis of synergism in small networks with different logic.Journal of biological physics · 2023Article
- Network analysis reveals that the tumor suppressor lncRNA GAS5 acts as a double-edged sword in response to DNA damage in gastric cancer.Scientific reports · 2022Article
- Probabilistic edge weights fine-tune Boolean network dynamics.PLoS computational biology · 2022Article
- A probabilistic Boolean model on hair follicle cell fate regulation by TGF-β.Biophysical journal · 2022Article
- Dynamical Analysis of a Boolean Network Model of the Oncogene Role of lncRNA ANRIL and lncRNA UFC1 in Non-Small Cell Lung Cancer.Biomolecules · 2022Article
- Parity and time reversal elucidate both decision-making in empirical models and attractor scaling in critical Boolean networks.Science advances · 2021Article
- Gene regulatory networks exhibit several kinds of memory: quantification of memory in biological and random transcriptional networks.iScience · 2021Article
- Mathematical modeling of the Candida albicans yeast to hyphal transition reveals novel control strategies.PLoS computational biology · 2021Article
- Modeling Progression of Single Cell Populations Through the Cell Cycle as a Sequence of Switches.Frontiers in molecular biosciences · 2021Article
- A Guard Cell Abscisic Acid (ABA) Network Model That Captures the Stomatal Resting State.Frontiers in physiology · 2020Article
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4 authors.
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Abstract
We perform logic-based network analysis on a model of the mammalian cell cycle. This model is composed of a Restriction Switch driving cell cycle commitment and a Phase Switch driving mitotic entry and exit. By generalizing the concept of stable motif, i.e., a self-sustaining positive feedback loop that maintains an associated state, we introduce the concept of a conditionally stable motif, the stability of which is contingent on external conditions. We show that the stable motifs of the Phase Switch are contingent on the state of three nodes through which it receives input from the rest of the network. Biologically, these conditions correspond to cell cycle checkpoints. Holding these nodes locked (akin to a checkpoint-free cell) transforms the Phase Switch into an autonomous oscillator that robustly toggles through the cell cycle phases G1, G2 and mitosis. The conditionally stable motifs of the Phase Switch Oscillator are organized into an ordered sequence, such that they serially stabilize each other but also cause their own destabilization. Along the way they channel the dynamics of the module onto a narrow path in state space, lending robustness to the oscillation. Self-destabilizing conditionally stable motifs suggest a general negative feedback mechanism leading to sustained oscillations.
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