ArticleScientific reports2019
Impact of bacteria motility in the encounter rates with bacteriophage in mucus.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- Unveiling the viral dimension: The paediatric gut virome as a key modulator of gastrointestinal metabolic, and neurodevelopmental health.World journal of virology · 2026Review
- Microgravity reshapes bacteriophage-host coevolution aboard the International Space Station.PLoS biology · 2026Article
- Structural Remodeling of Phage φPNJ-6 Hoc Promotes Adhesion to the Intestinal Epithelium.Transboundary and emerging diseases · 2026Article
- Multi-strain phage induced clearance of bacterial infections.PLoS computational biology · 2025Article
- The non-nutritive sweetener rebaudioside a enhances phage infectivity.Scientific reports · 2025Article
- Metapopulation model of phage therapy of an acutemSystems · 2024Article
- Synergistic action of bacteriophage and metabolites of Pseudomonas fluorescens JB3B and Streptomyces thermocarboxydus 18PM against Enterotoxigenic Escherichia coli and Bacillus cereus and their biofilm.BMC microbiology · 2024Article
- Multi-strain phage induced clearance of bacterial infections.bioRxiv : the preprint server for biology · 2024Article
- Metapopulation model of phage therapy of an acutebioRxiv : the preprint server for biology · 2024Article
- Native gastrointestinal mucus: Critical features and techniques for studying interactions with drugs, drug carriers, and bacteria.Advanced drug delivery reviews · 2023Review
- Mucin and Agitation Shape Predation ofMicroorganisms · 2023Article
- The dynamic interplay of bacteriophage, bacteria and the mammalian host during phage therapy.iScience · 2023Review
- Treatment of Wound Infections in a Mouse Model Using ZnACS nano · 2022Article
- Phage-encoded carbohydrate-interacting proteins in the human gut.Frontiers in microbiology · 2022Review
- Crosstalk between the Intestinal Virome and Other Components of the Microbiota, and Its Effect on Intestinal Mucosal Response and Diseases.Journal of immunology research · 2022Review
- Predicting the capsid architecture of phages from metagenomic data.Computational and structural biotechnology journal · 2022Article
- Bacteriophage-Bacteria Interactions in the Gut: From Invertebrates to Mammals.Annual review of virology · 2021Review
- Article
- Quantification of Lysogeny Caused by Phage Coinfections in Microbial Communities from Biophysical Principles.mSystems · 2020Article
- Interactions of Bacteriophages and Bacteria at the Airway Mucosa: New Insights Into the Pathophysiology of Asthma.Frontiers in allergy · 2020Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacteriophages-or phages-are viruses that infect bacteria and are present in large concentrations in the mucosa that cover the internal organs of animals. Immunoglobulin (Ig) domains on the phage surface interact with mucin molecules, and this has been attributed to an increase in the encounter rates of phage with bacteria in mucus. However, the physical mechanism behind this phenomenon remains unclear. A continuous time random walk (CTRW) model simulating the diffusion due to mucin-T4 phage interactions was developed and calibrated to empirical data. A Langevin stochastic method for Escherichia coli (E. coli) run-and-tumble motility was combined with the phage CTRW model to describe phage-bacteria encounter rates in mucus for different mucus concentrations. Contrary to previous theoretical analyses, the emergent subdiffusion of T4 in mucus did not enhance the encounter rate of T4 against bacteria. Instead, for static E. coli, the diffusive T4 mutant lacking Ig domains outperformed the subdiffusive T4 wild type. E. coli's motility dominated the encounter rates with both phage types in mucus. It is proposed, that the local fluid-flow generated by E. coli's motility combined with T4 interacting with mucins may be the mechanism for increasing the encounter rates between the T4 phage and E. coli bacteria.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.