Evidence map›Paper›PMID 31712450›Full record

ArticleAging2019

The TORC1 inhibitor Nprl2 protects age-related digestive function in

Junmeng Xi, Jiadong Cai, Yang Cheng, Yuanyuan Fu, Wanhong Wei, Zhenbo Zhang, Ziheng Zhuang, Yue Hao, Mary A Lilly, Youheng Wei

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. UsingCells · 2023
    Review
  3. Article
  4. International journal of molecular sciences · 2022
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Junmeng XiCollege of Bioscience and Biotechnology, Yangzhou University, Yangzhou, China.
Jiadong CaiCollege of Bioscience and Biotechnology, Yangzhou University, Yangzhou, China.
Yang ChengCollege of Bioscience and Biotechnology, Yangzhou University, Yangzhou, China.
Yuanyuan FuJoint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, Yangzhou, China.
Wanhong WeiCollege of Bioscience and Biotechnology, Yangzhou University, Yangzhou, China.
Zhenbo ZhangReproductive Medicine Center, Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ziheng ZhuangSchool of Pharmaceutical Engineering and Life Sciences, Changzhou University, Changzhou, China.
Yue HaoKey Laboratory of Pollinating Insect Biology, Ministry of Agriculture, Beijing, China.
Mary A LillyCell Biology and Neurobiology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Youheng WeiCollege of Bioscience and Biotechnology, Yangzhou University, Yangzhou, China.
Yangzhou University · CNChangzhou University · CNNational Institutes of Health · USShanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging and age-related diseases occur in almost all organisms. Recently, it was discovered that the inhibition of target of rapamycin complex 1 (TORC1), a conserved complex that mediates nutrient status and cell metabolism, can extend an individual's lifespan and inhibit age-related diseases in many model organisms. However, the mechanism whereby TORC1 affects aging remains elusive. Here, we use a loss-of-function mutation in

Indexed as

Gastrointestinal MotilityAgingAnimalsCarrier ProteinsDigestionDrosophilaDrosophila ProteinsMaleMechanistic Target of Rapamycin Complex 1Tumor Suppressor ProteinsCarrier ProteinsDrosophila ProteinsMechanistic Target of Rapamycin Complex 1Nprl2 protein, DrosophilaTumor Suppressor ProteinscropDrosophilagutNprl2Target of rapamycin complex 1 (TORC1)

Identifiers

PMID31712450
PMCPMC6874466
OpenAlexW2984602935

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.