Evidence map›Paper›PMID 31712417›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Structural studies of the eIF4E-VPg complex reveal a direct competition for capped RNA: Implications for translation.

Luciana Coutinho de Oliveira, Laurent Volpon, Amanda K Rahardjo, Michael J Osborne, Biljana Culjkovic-Kraljacic, Christian Trahan, Marlene Oeffinger, Benjamin H Kwok, Katherine L B Borden

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 79 citations in OpenAlex.

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  10. Fine mapping of the Chilli veinal mottle virus resistance 4 (cvr4) gene in pepper (Capsicum annuum L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Luciana Coutinho de OliveiraInstitute of Research in Immunology and Cancer, Department of Pathology and Cell Biology, Université de Montréal, Pavilion Marcelle-Coutu, Chemin Polytechnique, Montréal, QC H3T 1J4, Canada.ORCID 0000-0001-7167-8968
Laurent VolponInstitute of Research in Immunology and Cancer, Department of Pathology and Cell Biology, Université de Montréal, Pavilion Marcelle-Coutu, Chemin Polytechnique, Montréal, QC H3T 1J4, Canada.ORCID 0000-0002-7895-8863
Amanda K RahardjoInstitute of Research in Immunology and Cancer, Department of Pathology and Cell Biology, Université de Montréal, Pavilion Marcelle-Coutu, Chemin Polytechnique, Montréal, QC H3T 1J4, Canada.
Michael J OsborneInstitute of Research in Immunology and Cancer, Department of Pathology and Cell Biology, Université de Montréal, Pavilion Marcelle-Coutu, Chemin Polytechnique, Montréal, QC H3T 1J4, Canada.
Biljana Culjkovic-KraljacicInstitute of Research in Immunology and Cancer, Department of Pathology and Cell Biology, Université de Montréal, Pavilion Marcelle-Coutu, Chemin Polytechnique, Montréal, QC H3T 1J4, Canada.
Christian TrahanDepartment for Systems Biology, Institut de Recherches Cliniques de Montréal, Montréal, QC H2W 1R7, Canada.
Marlene OeffingerDepartment for Systems Biology, Institut de Recherches Cliniques de Montréal, Montréal, QC H2W 1R7, Canada.
Benjamin H KwokInstitute of Research in Immunology and Cancer, Department of Pathology and Cell Biology, Université de Montréal, Pavilion Marcelle-Coutu, Chemin Polytechnique, Montréal, QC H3T 1J4, Canada.
Katherine L B BordenInstitute of Research in Immunology and Cancer, Department of Pathology and Cell Biology, Université de Montréal, Pavilion Marcelle-Coutu, Chemin Polytechnique, Montréal, QC H3T 1J4, Canada; katherine.borden@umontreal.ca.
Institute for Research in Immunology and Cancer · CAMontreal Clinical Research Institute · CA

Funding

PROMYELOCYTIC LEUKEMIA PROTEINS ROLE IN APOPTOSISR01CA080728 · NCI · UNIVERSITY OF MONTREAL · PI KATHERINE L B BORDEN · 1999 to 2026
$5.3M
Molecular Mechanisms of eIF4E Mediated TransformationR01CA098571 · NCI · UNIVERSITY OF MONTREAL · PI BORDEN, KATHERINE L B, GUZMAN, MONICA L · 2003 to 2025
$5.0M
CIHR PJT159785NCI NIH HHS R01 CA080728NCI NIH HHS R01 CA098571
6 · The paper itself

Abstract

Viruses have transformed our understanding of mammalian RNA processing, including facilitating the discovery of the methyl-7-guanosine (m

Indexed as

Binding, CompetitiveBinding SitesCell LineEukaryotic Initiation Factor-4EHumansModels, MolecularNuclear Magnetic Resonance, BiomolecularPotyvirusProtein BiosynthesisProtein FoldingRibonucleoproteinsRNARNA CapsRNA Processing, Post-TranscriptionalViral ProteinsEukaryotic Initiation Factor-4ERibonucleoproteinsRNARNA CapsViral ProteinseIF4Em7 cappotyvirustranslationVPg

Identifiers

PMID31712417
PMCPMC6883836
OpenAlexW2984102294

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.