ArticleJournal of epidemiology and community health2020
Skeletal muscle mass in relation to 10 year cardiovascular disease incidence among middle aged and older adults: the ATTICA study.
Article in Journal of epidemiology and community health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
69 citing papers in PubMed, 3 syntheses or guidelines pooled it, 118 citations in OpenAlex.
- The Role of Fat-Free Mass in Weight-Related Complications: A Rapid Review and Meta-Analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Pooled it
- Body Composition and Risk of Incident Heart Failure in 1 Million Adults: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies.Journal of the American Heart Association · 2023Pooled it
- Validity of ultrasonography-derived predictions for estimating skeletal muscle volume: a systematic literature review.BMC medical imaging · 2021Pooled it
- Evenly Distributed Protein Intake over 3 Meals Augments Resistance Exercise-Induced Muscle Hypertrophy in Healthy Young Men.The Journal of nutrition · 2020Trial
- Examining the relationship between anthropometric and body composition measures with coronary heart disease events: the multi-ethnic study of atherosclerosis.European journal of preventive cardiology · 2026Article
- Macroscopic to ultrastructural analyses identify the loss of myofibrils as the primary mediator of ageing- and disuse-induced muscle fibre atrophy.The Journal of physiology · 2026Article
- Integrin-β1/FAK signaling is involved in electrical stimulation to prevent disuse muscular atrophy induced by tail suspension in mice.BMC musculoskeletal disorders · 2026Article
- Beyond Body Mass Index: Skeletal Muscle Mass as a Marker of Physiologic Reserve in Fontan Circulation.Pediatric cardiology · 2026Article
- Association between dietary macronutrients and body composition in college studentsAsia Pacific journal of clinical nutrition · 2026Article
- Muscle movement and metabolism: exercise and skeletal muscle as mediators of health-a report from the 26th Annual Harvard Nutrition Obesity Symposium, 2025.The American journal of clinical nutrition · 2026Article
- Article
- Resistance Exercise: A Potential Intervention for Managing Cardiovascular Health in Individuals with a History of Cancer.Sports medicine - open · 2026Article
- Relationship Between Body Composition With Carotid Intima Media Thickness in Young Adults: Tehran Lipid and Glucose Study.Endocrinology, diabetes & metabolism · 2026Article
- Muscle mass as a resilence factor for endothelial health in obesity.npj metabolic health and disease · 2026Review
- Normalized creatinine-to-cystatin C ratio and cardiovascular disease risk in populations with cardiovascular-kidney-metabolic syndrome stages 0-3: findings from a national and prospective cohort study.European journal of medical research · 2026Article
- Aging strong: an N = 1 mixed-methods study of long-term supervised high-intensity resistance training in a 71-year-old woman.Frontiers in aging · 2026Article
- Adverse Muscle Composition Is an Early Feature of Chronic Kidney Disease and Associates With Poor Function and Comorbidities.Kidney medicine · 2026Article
- Dynapenic abdominal obesity and the risk of cardiovascular diseases: findings from the China Health and Retirement Longitudinal Study.Aging clinical and experimental research · 2025Article
- High adiposity linked to presarcopenia and decreased cardiorespiratory fitness in sedentary young Indians independent of their high-fat-salt-sugar (HFSS) food frequency.Scientific reports · 2025Article
- Impact of Muscle Mass on the Performance of Creatinine-Based eGFR Equations and Mortality Risk Assessment After Kidney Transplantation.Journal of cachexia, sarcopenia and muscle · 2025Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundSkeletal muscle mass (SMM) is inversely associated with cardiometabolic health and the ageing process. The aim of the present work was to evaluate the relation between SMM and 10 year cardiovascular disease (CVD) incidence, among CVD-free adults 45+ years old.
methodsATTICA is a prospective, population-based study that recruited 3042 adults without pre-existing CVD from the Greek general population (Caucasians; age ≥18 years; 1514 men). The 10 year study follow-up (2011-2012) captured the fatal/non-fatal CVD incidence in 2020 participants (50% men). The working sample consisted of 1019 participants, 45+ years old (men: n=534; women: n=485). A skeletal muscle mass index (SMI) was created to reflect SMM, using appendicular skeletal muscle mass (ASM) standardised by body mass index (BMI). ASM and SMI were calculated with specific indirect population formulas.
resultsThe 10 year CVD incidence increased significantly across the baseline SMI tertiles (p<0.001). Baseline SMM showed a significant inverse association with the 10 year CVD incidence (HR 0.06, 95% CI 0.005 to 0.78), even after adjusting for various confounders. Additionally, participants in the highest SMM tertile had 81% (95% CI 0.04 to 0.85) lower risk for a CVD event as compared with those in the lowest SMM tertile.
conclusionsThe presented findings support the importance of SMM evaluation in the prediction of long-term CVD risk among adults 45+ years old without pre-existing CVD. Preservation of SMM may contribute to CVD health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.