ArticleCell chemical biology2020
Antitubercular Triazines: Optimization and Intrabacterial Metabolism.
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Article in Cell chemical biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22citing papers in PubMed
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Who cites it
22 citing papers in PubMed.
- Identification of chemical features for improved outer membrane permeation in mycobacteria using machine learning.Nature microbiology · 2026Article
- The Quantification of Drug Accumulation within Gram-Negative Bacteria.ACS infectious diseases · 2026Article
- Defining the mechanism of action of the nitrofuranyl piperazine HC2210 against Mycobacterium abscessus.npj antimicrobials and resistance · 2025Article
- Exploring the Potential of s-Triazine Derivatives as Novel Antifungal Agents: A Review.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Efflux pumps and membrane permeability contribute to intrinsic antibiotic resistance in Mycobacterium abscessus.PLoS pathogens · 2025Article
- Functions of nitroreductases in mycobacterial physiology and drug susceptibility.Journal of bacteriology · 2025Review
- A folate inhibitor exploits metabolic differences in Pseudomonas aeruginosa for narrow-spectrum targeting.Nature microbiology · 2024Article
- Small Molecule Benzothiophene withJournal of medicinal chemistry · 2024Article
- Discovery and characterization of antimycobacterial nitro-containing compounds with distinct mechanisms of action andAntimicrobial agents and chemotherapy · 2023Article
- Asymmetric Synthesis of US-FDA Approved Drugs over Five Years (2016-2020): A Recapitulation of Chirality.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Identification of Small Molecule Inhibitors against Mycobacteria in Activated Macrophages.Molecules (Basel, Switzerland) · 2022Article
- Random Forest Model Predictions Afford Dual-Stage Antimalarial Agents.ACS infectious diseases · 2022Article
- Review
- Bayesian Modeling and Intrabacterial Drug Metabolism Applied to Drug-ResistantACS infectious diseases · 2021Article
- Targeting Mycobacterium tuberculosis response to environmental cues for the development of effective antitubercular drugs.PLoS biology · 2021Article
- Random Forest Model Prediction of Compound Oral Exposure in the Mouse.ACS pharmacology & translational science · 2021Article
- Molecule Property Analyses of Active Compounds forJournal of medicinal chemistry · 2020Review
- Morphological profiling of tubercle bacilli identifies drug pathways of action.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Synthesis, Characterization, and Biologic Activity of New Acyl Hydrazides and 1,3,4-Oxadiazole Derivatives.Molecules (Basel, Switzerland) · 2020Article
- Machine Learning Platform to Discover Novel Growth Inhibitors of Neisseria gonorrhoeae.Pharmaceutical research · 2020Article
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Authors and funding
26 authors.
Xin WangDepartment of Pharmacology, Physiology and Neuroscience, Rutgers University - New Jersey Medical School, Newark, NJ 07103, USA.
Daigo InoyamaDepartment of Pharmacology, Physiology and Neuroscience, Rutgers University - New Jersey Medical School, Newark, NJ 07103, USA.
Riccardo RussoDivision of Infectious Disease, Department of Medicine and the Ruy V. Lourenço Center for the Study of Emerging and Re-emerging Pathogens, Rutgers University - New Jersey Medical School, Newark, NJ 07103, USA.
Shao-Gang LiDepartment of Pharmacology, Physiology and Neuroscience, Rutgers University - New Jersey Medical School, Newark, NJ 07103, USA.
Ravindra JadhavDepartment of Pharmacology, Physiology and Neuroscience, Rutgers University - New Jersey Medical School, Newark, NJ 07103, USA.
Thomas P StrattonDepartment of Pharmacology, Physiology and Neuroscience, Rutgers University - New Jersey Medical School, Newark, NJ 07103, USA.
Nisha MittalDepartment of Pharmacology, Physiology and Neuroscience, Rutgers University - New Jersey Medical School, Newark, NJ 07103, USA.
Joseph A BilottaDepartment of Pharmacology, Physiology and Neuroscience, Rutgers University - New Jersey Medical School, Newark, NJ 07103, USA.
Eric SingletonDivision of Infectious Disease, Department of Medicine and the Ruy V. Lourenço Center for the Study of Emerging and Re-emerging Pathogens, Rutgers University - New Jersey Medical School, Newark, NJ 07103, USA.
Thomas KimDivision of Infectious Disease, Department of Medicine and the Ruy V. Lourenço Center for the Study of Emerging and Re-emerging Pathogens, Rutgers University - New Jersey Medical School, Newark, NJ 07103, USA.
Steve D PagetDepartment of Pharmacology, Physiology and Neuroscience, Rutgers University - New Jersey Medical School, Newark, NJ 07103, USA.
Richard S PottorfDepartment of Pharmacology, Physiology and Neuroscience, Rutgers University - New Jersey Medical School, Newark, NJ 07103, USA.
Yong-Mo AhnDepartment of Pharmacology, Physiology and Neuroscience, Rutgers University - New Jersey Medical School, Newark, NJ 07103, USA.
Alejandro Davila-PaganDepartment of Pharmacology, Physiology and Neuroscience, Rutgers University - New Jersey Medical School, Newark, NJ 07103, USA.
Srinivasan KandasamyDepartment of Pharmacology, Physiology and Neuroscience, Rutgers University - New Jersey Medical School, Newark, NJ 07103, USA.
Courtney GradyDivision of Infectious Disease, Department of Medicine and the Ruy V. Lourenço Center for the Study of Emerging and Re-emerging Pathogens, Rutgers University - New Jersey Medical School, Newark, NJ 07103, USA.
Seema HussainGenomics Center, Rutgers University - New Jersey Medical School, Newark, NJ 07103, USA; Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers University - New Jersey Medical School, Newark, NJ 07103, USA.
Patricia SoteropoulosGenomics Center, Rutgers University - New Jersey Medical School, Newark, NJ 07103, USA; Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers University - New Jersey Medical School, Newark, NJ 07103, USA.
Matthew D ZimmermanPublic Health Research Institute, Rutgers University - New Jersey Medical School, Newark, NJ, USA.
Hsin Pin HoPublic Health Research Institute, Rutgers University - New Jersey Medical School, Newark, NJ, USA.
Steven ParkPublic Health Research Institute, Rutgers University - New Jersey Medical School, Newark, NJ, USA.
Véronique DartoisPublic Health Research Institute, Rutgers University - New Jersey Medical School, Newark, NJ, USA.
Sean EkinsCollaborations in Chemistry Inc., Raleigh, NC 27606, USA.
Nancy ConnellDivision of Infectious Disease, Department of Medicine and the Ruy V. Lourenço Center for the Study of Emerging and Re-emerging Pathogens, Rutgers University - New Jersey Medical School, Newark, NJ 07103, USA.
Pradeep KumarDivision of Infectious Disease, Department of Medicine and the Ruy V. Lourenço Center for the Study of Emerging and Re-emerging Pathogens, Rutgers University - New Jersey Medical School, Newark, NJ 07103, USA.
Joel S FreundlichDepartment of Pharmacology, Physiology and Neuroscience, Rutgers University - New Jersey Medical School, Newark, NJ 07103, USA; Division of Infectious Disease, Department of Medicine and the Ruy V. Lourenço Center for the Study of Emerging and Re-emerging Pathogens, Rutgers University - New Jersey Medical School, Newark, NJ 07103, USA. Electronic address: freundjs@rutgers.edu.
Funding
Therapeutics for drug-resistant bacteria: aryl myxopyronins and arylalkylcarboxamido phloroglucinolsU19AI142731 · NIAID · HACKENSACK UNIVERSITY MEDICAL CENTER · PI ALLAND, DAVID · 2019 to 2023
$33.9MTherapeutics for drug resistant-bacteria: Arylpropionyl-phloroglucinolsU19AI109713 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI CONNELL, NANCY D. · 2014 to 2018
$26.9MSupercomputing: Rutgers' Catalyst for Discovery at the Frontiers of MedicineS10OD012346 · OD · RBHS-NEW JERSEY MEDICAL SCHOOL · PI MICHELSON, LESLIE PAUL · 2015 to 2015
$1.7MA QTRAP 6500 LC-MS/MS System from SCIEX for high accuracy drug content analysisS10OD023524 · OD · RBHS-NEW JERSEY MEDICAL SCHOOL · PI DARTOIS, VERONIQUE · 2017 to 2017
$526kIllumina NextSeq500 DNA Sequencing SystemS10OD018206 · OD · RBHS-NEW JERSEY MEDICAL SCHOOL · PI TIAN, BIN · 2015 to 2015
$227kOptimization of small molecule triazine antituberculars for in vivo efficacyR41AI122434 · NIAID · COLLABORATIONS PHARMACEUTICALS, INC. · PI EKINS, SEAN · 2016 to 2016
$149kNIAID NIH HHS R41 AI122434NIAID NIH HHS U19 AI109713NIAID NIH HHS U19 AI142731NIH HHS S10 OD012346NIH HHS S10 OD018206NIH HHS S10 OD023524
Abstract
The triazine antitubercular JSF-2019 was of interest due to its in vitro efficacy and the nitro group shared with the clinically relevant delamanid and pretomanid. JSF-2019 undergoes activation requiring F
Indexed as
AnimalsAntitubercular AgentsBacterial ProteinsDrug Resistance, BacterialFatty Acid SynthasesFemaleHalf-LifeMiceMice, Inbred BALB CMicrobial Sensitivity TestsMycobacterium tuberculosisNitric OxideOxidoreductasesTriazinesAntitubercular AgentsBacterial ProteinsF420H2 dehydrogenaseFatty Acid SynthasesInhA protein, MycobacteriumNitric OxideOxidoreductasesTriazinesBayesian modelsintrabacterial drug metabolismMycobacterium tuberculosisnitrofurantriazine
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