Evidence map›Paper›PMID 31711815›Full record

ReviewNeuroscience and biobehavioral reviews2020

Opposite-sex and same-sex twin studies of physiological, cognitive and behavioral traits.

Linda Juel Ahrenfeldt, Kaare Christensen, Nancy L Segal, Yoon-Mi Hur

Open access · greenAbstract readReviewTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuroscience and biobehavioral reviews, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. On the importance of including both sexes in animal studies - insights from home-cage monitoring.Biological reviews of the Cambridge Philosophical Society · 2026
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Expression and Role of INSL3 in the Fetal Testis.Frontiers in endocrinology · 2022
    Review
  10. The Person's Care Requires a Sex and Gender Approach.Journal of clinical medicine · 2021
    Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

Linda Juel AhrenfeldtUnit of Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, 5000, Odense, Denmark; The Danish Twin Registry, Department of Public Health, University of Southern Denmark, 5000, Odense, Denmark.
Kaare ChristensenUnit of Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, 5000, Odense, Denmark; The Danish Twin Registry, Department of Public Health, University of Southern Denmark, 5000, Odense, Denmark; Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, 5000, Odense, Denmark; Department of Clinical Genetics, Odense University Hospital, 5000 Odense, Denmark.
Nancy L SegalDepartment of Psychology, California State University, 800 N. State College Blvd., Fullerton, CA, 92834, USA.
Yoon-Mi HurEducation Research Institute, Department of Education, Mokpo National University, Jeonnam, South Korea. Electronic address: ymhur@mokpo.ac.kr.
University of Southern Denmark · DKCalifornia State University, Fullerton · USMokpo National University · KR

Funding

TRAJECTORIES OF MORTALITY IN CAENORHABDITIS ELEGANSP01AG008761 · NIA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI VAUPEL, JAMES W. · 1990 to 2008
$17.5M
THE RANGE OF MALE-FEMALE MORTALITY DIFFERENCESP01AG031719 · NIA · DUKE UNIVERSITY · PI CHRISTENSEN, KAARE · 2009 to 2020
$10.2M
NIA NIH HHS P01 AG008761NIA NIH HHS P01 AG031719
6 · The paper itself

Abstract

A scientific interest in opposite-sex (OS) twins comes from animal studies showing hormone transfer between fetuses in utero. A parallel effect in humans may occur, especially for OS females who may be exposed to androgens, in particular testosterone, from the male co-twin. Conversely, OS males may be exposed to lower levels of prenatal testosterone than do same-sex (SS) males. In this special issue, we reviewed published studies investigating potential differences between OS and SS twins in physiological, cognitive and behavioral traits focusing on the Twin Testosterone Transfer (TTT) hypothesis. Sixty articles fulfilled the eligibility criteria including 23 studies published since the review by Tapp et al. (2011). In general, studies of cognition are conflicting, but it is the phenotype for which most support for the TTT hypothesis is found. Less consistent evidence has been found regarding physiological and behavioral traits. We hope that this special issue will stimulate a discussion about how an investigation of the TTT hypothesis should continue in future research.

Indexed as

Sex CharacteristicsSocial BehaviorTwinsAnimalsFemaleHuman DevelopmentHumansMalePersonalityPregnancyPregnancy, TwinTestosteroneTestosteroneBehaviorCognitionMasculinizationOpposite-sexPhysiologySame-sexSex differencesTestosteroneTwins

Identifiers

PMID31711815
PMCPMC6949417
OpenAlexW2987974742

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.