Evidence map›Paper›PMID 31711660›Full record

ArticleEnvironmental research2020

A possible relationship between telomere length and markers of neurodegeneration in rat brain after welding fume inhalation exposure.

Mohammad Shoeb, Gul M Mustafa, Vamsi K Kodali, Kelly Smith, Katherine A Roach, Gregory Boyce, Terence Meighan, Jenny R Roberts, Aaron Erdely, James M Antonini

Open access · greenAbstract read
In one paragraph

Article in Environmental research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Profiling Metal-Induced Genotoxic Endpoints.Journal of environmental health · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Telomeres in toxicology: Occupational health.Pharmacology & therapeutics · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Mohammad ShoebHealth Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA. Electronic address: ywo7@cdc.gov.
Gul M MustafaHealth Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA.
Vamsi K KodaliHealth Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA.
Kelly SmithHealth Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA.
Katherine A RoachHealth Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA.
Gregory BoyceHealth Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA.
Terence MeighanHealth Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA.
Jenny R RobertsHealth Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA.
Aaron ErdelyHealth Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA.
James M AntoniniHealth Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA.
National Institute for Occupational Safety and Health · US

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

Inhalation of welding fume (WF) can result in the deposition of toxic metals, such as manganese (Mn), in the brain and may cause neurological changes in exposed workers. Alterations in telomere length are indicative of cellular aging and, possibly, neurodegeneration. Here, we investigated the effect of WF inhalation on telomere length and markers of neurodegeneration in whole brain tissue in rats. Male Fischer-344 (F-344) rats were exposed by inhalation to stainless steel WF (20 mg/m

Indexed as

Air Pollutants, OccupationalInhalation ExposureTelomereWeldingAnimalsBrainCatsDNA MethylationEndothelial CellsGene Expression RegulationHumansMaleRatsRats, Sprague-DawleyAir Pollutants, OccupationalDNA damageTelomereTrf1Trf2Welding fumes

Identifiers

PMID31711660
PMCPMC6899181
OpenAlexW2986005096

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.