Evidence map›Paper›PMID 31711569›Full record

ArticleeLife2019

The effects of psychosocial stress on dopaminergic function and the acute stress response.

Michael Ap Bloomfield, Robert A McCutcheon, Matthew Kempton, Tom P Freeman, Oliver Howes

Open access · goldAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 3 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 3 syntheses or guidelines pooled it, 113 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Opioid-blunted cortisol response to stress is associated with increased negative mood and wanting of social reward.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
    Trial
  7. Trial
  8. Trial
  9. Article
  10. Article
  11. Observational
  12. Article
  13. How dopamine guides our social world.Pharmacological reviews · 2025
    Review
  14. Attenuation Effect ofInternational journal of molecular sciences · 2025
    Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Michael Ap BloomfieldPsychiatric Imaging Group, MRC London Institute of Medical Sciences, Imperial College London, London, United Kingdom.ORCID 0000-0002-1972-4610
Robert A McCutcheonPsychiatric Imaging Group, MRC London Institute of Medical Sciences, Imperial College London, London, United Kingdom.ORCID 0000-0003-1102-2566
Matthew KemptonDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, London, United Kingdom.
Tom P FreemanTranslational Psychiatry Research Group, Research Department of Mental Health Neuroscience, Division of Psychiatry, UCL Institute of Mental Health, University College London, London, United Kingdom.
Oliver HowesPsychiatric Imaging Group, MRC London Institute of Medical Sciences, Imperial College London, London, United Kingdom.
King's College London · GBMental Health Research UK · GBUniversity College London Hospitals NHS Foundation Trust · GB

Funding

Medical Research Council G0700995Medical Research Council MC-A656-5QD30Medical Research Council MC_U120097115Medical Research Council MR/L022176/1Medical Research Council MR/N026063/1Medical Research Council MR/N027078/1National Institute for Health Research Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College LondonNational Institute for Health Research University College London Hospitals Biomedical Research CentreWellcome Trust 094849/Z/10/Z
6 · The paper itself

Abstract

Chronic psychosocial adversity induces vulnerability to mental illnesses. Animal studies demonstrate that this may be mediated by dopaminergic dysfunction. We therefore investigated whether long-term exposure to psychosocial adversity was associated with dopamine dysfunction and its relationship to psychological and physiological responses to acute stress. Using 3,4-dihydroxy-6-[

Indexed as

Stress, PsychologicalAdultChildCorpus StriatumDopamineFemaleHumansMalePositron-Emission TomographyYoung AdultDopamineadversityhumanimagingneurosciencePETpsychosocialstressthreat

Identifiers

PMID31711569
PMCPMC6850765
OpenAlexW2989069730

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.