ArticleRadiation oncology (London, England)2019
Wound monitoring of pH and oxygen in patients after radiation therapy.
Article in Radiation oncology (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 37 citations in OpenAlex.
- Functionalized hydrogel sequentially deliver tannic acid and bioactive probiotics for radiation-induced skin injury.Materials today. Bio · 2026Article
- Stimuli-responsive hydrogels for radiation-induced skin injury: from passive barriers to autonomous drug delivery systems.Regenerative biomaterials · 2026Review
- Interactions Between Active Matters and Endogenous Fields.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Multimodal Function of Mesenchymal Stem Cells in Psoriasis Treatment.Biomolecules · 2025Review
- Longitudinal analysis of microcirculatory parameters in gingival tissues after tooth extraction in patients with different risk profiles for wound healing disorders - a pilot study.Clinical oral investigations · 2024Article
- Management of irradiated post-mastectomy wound dehiscence with synthetic electrospun fiber matrix: a case report.Frontiers in oncology · 2024Article
- Quantification of oxygen consumption in head and neck cancer using fluorescent sensor foil technology.Frontiers in oncology · 2024Article
- High-resolution spatiotemporal pHCancer & metabolism · 2021Article
- Observational
- Will mesenchymal stem cells be future directions for treating radiation-induced skin injury?Stem cell research & therapy · 2021Review
- Fluorescein Derivatives as Fluorescent Probes for pH Monitoring along Recent Biological Applications.International journal of molecular sciences · 2020Review
- A paintable phosphorescent bandage for postoperative tissue oxygen assessment in DIEP flap reconstruction.Science advances · 2020Article
- Optical Sensing and Imaging of pH Values: Spectroscopies, Materials, and Applications.Chemical reviews · 2020Article
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
objectivesPostradiogenic wound healing disorders are an important clinical problem. While a variety of treatment modalities are available, there is no strategy to objectively judge treatment success. The aim of this study was to evaluate a 2D luminescence imaging system for pH and oxygen in non-healing wounds after radiotherapy.
methodsLuminescence 2D imaging was performed with the VisiSens (Presens, Regensburg, Germany) 2D imaging systems A1 and A2 for oxygen and pH, respectively. Biocompatible planar luminescent sensor foils were applied to non-irradiated and irradiated skin as well as to radiogenic wounds of five patients and the pH and the oxygen saturation was determined.
resultspH measurements showed significant differences between non-irradiated skin (6.46 ± 0.18) and irradiated skin (6.96 ± 0.26). Radiogenic wounds exhibited the highest pH values (7.53 ± 0.26). Oxygen measurements revealed a mean oxygen saturation of non-irradiated skin of 6.19 ± 0.83 mmHg. The highest value of oxygen saturation (28.4 ± 2.4 mmHg) was found on irradiated skin while irradiated wounds had a poor oxygen saturation (9.4 ± 2.2 mmHg) (mean ± s.e.m.).
conclusionWe found that routine measurement of pH and pO2 in patients could be easily integrated into the clinical routine. The results of the measurements show unfavorable pH and oxygen saturation conditions for wound healing in irradiated wounds. Interestingly, irradiated wounds exhibit a more pronounced hypoxia than irradiated skin which is reflected by an altered pH and pO2 compared to unirradiated skin, which has the potential to serve as a prognostic marker in the future. In addition to the objectification of the treatment success of postradiogenic wound healing disorders, the extent of skin toxicity could already be predicted during radiotherapy with this method.
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