Evidence map›Paper›PMID 31711499›Full record

Trial reportBMC health services research2019

Cost-effectiveness of the SLIMMER diabetes prevention intervention in Dutch primary health care: economic evaluation from a randomised controlled trial.

Geerke Duijzer, Andrea J Bukman, Aafke Meints-Groenveld, Annemien Haveman-Nies, Sophia C Jansen, Judith Heinrich, Gerrit J Hiddink, Edith J M Feskens, G Ardine de Wit

Registry-linked trialAbstract readComparative StudyMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC health services research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02094911 (Implementation and), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02094911 naunknown statusnot on this map

Implementation and (Cost-)Effectiveness of Diabetes Prevention in Dutch Primary Health Care: From SLIM to SLIMMER

TypeinterventionalSponsorWageningen UniversityRan2011 to 2015Enrolled316ConditionsDiabetes Mellitus Type 2ArmsCombined lifestyle intervention, Usual care group
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Review
  3. Review
  4. Health educationFrontiers in public health · 2022
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Geerke DuijzerWageningen University, Division of Human Nutrition; Academic Collaborative Centre AGORA, PO Box 17, 6700 AA, Wageningen, the Netherlands. g.duijzer@ggdnog.nl.ORCID http://orcid.org/0000-0002-5733-236X
Andrea J BukmanWageningen University, Division of Human Nutrition; Academic Collaborative Centre AGORA, PO Box 17, 6700 AA, Wageningen, the Netherlands.
Aafke Meints-GroenveldWageningen University, Division of Human Nutrition; Academic Collaborative Centre AGORA, PO Box 17, 6700 AA, Wageningen, the Netherlands.
Annemien Haveman-NiesWageningen University, Division of Human Nutrition; Academic Collaborative Centre AGORA, PO Box 17, 6700 AA, Wageningen, the Netherlands.
Sophia C JansenGGD Noord- en Oost-Gelderland (Community Health Service), PO Box 3, 7200 AA, Warnsveld, the Netherlands.
Judith HeinrichGGD Noord- en Oost-Gelderland (Community Health Service), PO Box 3, 7200 AA, Warnsveld, the Netherlands.
Gerrit J HiddinkStrategic Communication, Sub-department Communication, Philosophy and Technology: Centre for Integrative Development, Social Sciences, Wageningen University, PO Box 8130, 6700 EW, Wageningen, the Netherlands.
Edith J M FeskensWageningen University, Division of Human Nutrition; Academic Collaborative Centre AGORA, PO Box 17, 6700 AA, Wageningen, the Netherlands.
G Ardine de WitJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Julius Centrum, PO Box 85500, STR 6.131, 3508 GA, Utrecht, the Netherlands.

Funding

Diabetes Fonds 2011.15.1462ZonMw 20400.7003ZonMw 87600048
6 · The paper itself

Abstract

backgroundAlthough evidence is accumulating that lifestyle modification may be cost-effective in patients with prediabetes, information is limited on the cost-effectiveness of interventions implemented in public health and primary health care settings. Evidence from well-conducted pragmatic trials is needed to gain insight into the realistic cost-effectiveness of diabetes prevention interventions in real-world settings. The aim of this study is to assess the cost-effectiveness of the SLIMMER lifestyle intervention targeted at patients at high risk of developing type 2 diabetes compared with usual health care in a primary care setting in the Netherlands.

methodsThree hundred and sixteen high-risk subjects were randomly assigned to the SLIMMER lifestyle intervention or to usual health care. Costs and outcome assessments were performed at the end of the intervention (12 months) and six months thereafter (18 months). Costs were assessed from a societal perspective. Patients completed questionnaires to assess health care utilisation, participant out-of-pocket costs, and productivity losses. Quality Adjusted Life Years (QALY) were calculated based on the SF-36 questionnaire. Cost-effectiveness planes and acceptability curves were generated using bootstrap analyses.

resultsThe cost-effectiveness analysis showed that the incremental costs of the SLIMMER lifestyle intervention were €547 and that the incremental effect was 0.02 QALY, resulting in an incremental cost-effectiveness ratio (ICER) of €28,094/QALY. When cost-effectiveness was calculated from a health care perspective, the ICER decreased to €13,605/QALY, with a moderate probability of being cost-effective (56% at a willingness to pay, WTP, of €20,000/QALY and 81% at a WTP of €80,000/QALY).

conclusionsThe SLIMMER lifestyle intervention to prevent type 2 diabetes had a low to moderate probability of being cost-effective, depending on the perspective taken.

trial registrationThe SLIMMER study is retrospectively registered with ClinicalTrials.gov (Identifier NCT02094911) since March 19, 2014.

Indexed as

AdultAgedCost-Benefit AnalysisDiabetes Mellitus, Type 2FemaleGeneral PracticeHealth ExpendituresHealthy LifestyleHumansMaleMiddle AgedNetherlandsOutcome Assessment, Health CarePrimary Health CareQuality-Adjusted Life YearsQuality of LifeCost-effectivenessDiabetesEconomic evaluationLifestyle interventionPrevention

Identifiers

PMID31711499
PMCPMC6849241

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.