ArticleBMC complementary and alternative medicine2019
Sedative and hypnotic effects of compound Anshen essential oil inhalation for insomnia.
Article in BMC complementary and alternative medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.
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Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effects of Essential Oils and Fragrant Compounds on Appetite: A Systematic Review.International journal of molecular sciences · 2023Pooled it
- Lavender aromatherapy: A systematic review from essential oil quality and administration methods to cognitive enhancing effects.Applied psychology. Health and well-being · 2022Pooled it
- A Review on Ylang-Ylang (Molecules (Basel, Switzerland) · 2026Review
- Intranasal essential oils in therapy: advances in clinical applications and delivery mechanisms.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2026Review
- Huanglian Wendan decoction modulates gut microbiota-brain axis for depression comorbid with insomnia: a mini review.Frontiers in microbiology · 2026Review
- Review
- Limonene alleviated ulcerative colitis via anti-inflammation, anti-oxidation and regulating intestinal microenvironment in vivo and in vitro.Inflammopharmacology · 2025Article
- Volatile Essential Oils from Different Tree Species Influence Scent Impression and Physiological Response.Molecules (Basel, Switzerland) · 2025Article
- Caffeine and sclareol take the edge off the sedative effects of linalool, possibly through the GABAA interaction pathway: molecular insights through in vivo and in silico studies.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Anti-Anxiety Effects of Essential Oil Microemulsion in Chronic Unpredictable Mild Stress-Induced Rats: Preparation, Characterization, and Mechanisms.Molecules (Basel, Switzerland) · 2025Article
- Baihe Dihuang Tang as a therapeutic candidate for insomnia: Targeting gut dysbiosis and neuroendocrine dysfunction.iMetaOmics · 2025Article
- Comparative Analysis of Chemical Composition and Antibacterial Activity of Essential Oils from Five Varieties ofMolecules (Basel, Switzerland) · 2025Article
- An analysis of electroacupuncture as adjunctive treatment for insomnia: a new perspective targeting GABA-mediated microbiome-gut-brain axis.Frontiers in neurology · 2025Article
- Gut microbiota and insomnia: Mendelian randomization and network pharmacology to predict potential intervention with traditional Chinese medicine.Archives of medical science : AMS · 2025Article
- Long-lasting effects of lavender exposure on brain resting-state networks in healthy women.Frontiers in neuroscience · 2025Article
- The Role of Essential Oils on Sleep Quality and Other Sleep-related Issues: Evidence from Clinical Trials.Mini reviews in medicinal chemistry · 2025Review
- Aromatherapy was used to explore the sedative and hypnotic effects ofFood science & nutrition · 2024Article
- Sedative-Hypnotic Effect and Mechanism of Carbon Nanofiber Loaded with Essential Oils ofBiomolecules · 2024Article
- Beta-Myrcene as a Sedative-Hypnotic Component from Lavender Essential Oil in DL-4-Chlorophenylalanine-Induced-Insomnia Mice.Pharmaceuticals (Basel, Switzerland) · 2024Article
- The effect of modified Qiyuan paste on mice with low immunity and sleep deprivation by regulating GABA nerve and immune system.Chinese medicine · 2024Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
backgroundsThe chemical composition of many essential oils indicates that they have sedative and hypnotic effects, but there is still a lack of systematic studies on the sedative and hypnotic effects of essential oils. In addition, aromatherapy does not seem to have the side effects of many traditional psychotropic substances, which is clearly worthwhile for further clinical and scientific research. The clinical application of essential oils in aromatherapy has received increasing attention, and detailed studies on the pharmacological activities of inhaled essential oils are increasingly needed. HYPOTHESIS/PURPOSE: As insomniacs are usually accompanied by symptoms of depression and anxiety of varying degrees, based on the theory of aromatherapy of Traditional Chinese Medicine, this experiment is to study a Compound Anshen essential oil that is compatible with Lavender essential oil, Sweet Orange essential oil, Sandalwood essential oil and other aromatic medicine essential oils with sedative and hypnotic effects, anti-anxiety and anti-depression effects. To study the sedative and hypnotic effects of Compound Anshen essential oil inhaled and the main chemical components of Compound Anshen essential oil, and to compare and analyze the pharmacodynamics of diazepam, a commonly used drug for insomnia.
methodsThe Open field test and Pentobarbital-induced sleep latency and sleep time experiments were used to analyze and compare the sedative and hypnotic effects of inhaling Compound Anshen essential oil and the administration of diazepam on mice. The changes of 5-HT and GABA in mouse brain were analyzed by Elisa. The main volatile constituents of Compound Anshen essential oil were analyzed by gas chromatography-mass spectrometry (GC-MS).
resultsInhalation of Compound Anshen essential oil can significantly reduce the spontaneous activity of mice, reduce latency of sleeping time and prolong duration of sleeping time. The results of enzyme-linked immunosorbent assay showed that Compound Anshen essential oil can increase the content of 5-HT and GABA in mouse brain. The main volatile chemical constituents of the Compound Anshen essential oil are D-limonene (24.07%), Linalool (21.98%), Linalyl acetate (15.37%), α-Pinene (5.39%), and α-Santalol (4.8%).
conclusionThe study found that the inhalation of Compound Anshen essential oil has sedative and hypnotic effect. This study provides a theoretical basis for further research and development of the sedative and hypnotic effects of Compound Anshen essential oil based on the theory of aromatherapy.
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