ArticleCerebral cortex (New York, N.Y. : 1991)2020
Movement and Performance Explain Widespread Cortical Activity in a Visual Detection Task.
Article in Cerebral cortex (New York, N.Y. : 1991), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers.
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Who cites it
110 citing papers in PubMed.
- Medial premotor cortex as a potential reservoir of reward expectancy signals influencing the primate frontoparietal network.Communications biology · 2026Article
- Sensory-to-motor transformations: From serial pipelines to dynamic, distributed processes.Neuroscience and biobehavioral reviews · 2026Review
- Age-related changes in behavioural and neural variability in a decision-making task.Nature communications · 2026Article
- Article
- Population-level encoding of task information is stronger in the adolescent compared to adult frontal cortex.Developmental cognitive neuroscience · 2026Article
- Anterior cingulate neurons combine outcome monitoring of past decisions with ongoing movement signals.Nature communications · 2026Article
- Control of cortical population activity with patterned microstimulation.bioRxiv : the preprint server for biology · 2026Article
- Article
- How distributed is the brain-wide network that is recruited for cognition?Nature reviews. Neuroscience · 2026Review
- Convergence of Cortical and Thalamic Origins of Free Behavior Modulation of Mouse Primary Visual Cortex.bioRxiv : the preprint server for biology · 2026Article
- Brain-wide analysis reveals movement encoding structured across and within brain areas.Nature neuroscience · 2026Article
- Routing of task-relevant information in mouse PPC during continuous visuomotor control.bioRxiv : the preprint server for biology · 2025Article
- Facial expressions in mice reveal latent cognitive variables and their neural correlates.Nature neuroscience · 2025Article
- Selective coupling and decoupling coordinate distributed brain networks for precise action.bioRxiv : the preprint server for biology · 2025Article
- Map of spiking activity underlying change detection in the mouse visual system.bioRxiv : the preprint server for biology · 2025Article
- Spontaneous movements and their relationship to neural activity fluctuate with latent engagement states.Neuron · 2025Article
- Orexin population activity precisely reflects net body movement across behavioral and metabolic states.eLife · 2025Article
- Characterizing optogenetically mediated rebound effects in anaesthetized mouse primary visual cortex.The Journal of physiology · 2025Article
- Inferring internal states across mice and monkeys using facial features.Nature communications · 2025Article
- Thalamic feedback shapes brain responses evoked by cortical stimulation in mice and humans.Nature communications · 2025Article
50 more citing papers are in PubMed but not listed here.
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4 authors.
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Abstract
Recent studies in mice reveal widespread cortical signals during task performance; however, the various task-related and task-independent processes underlying this activity are incompletely understood. Here, we recorded wide-field neural activity, as revealed by GCaMP6s, from dorsal cortex while simultaneously monitoring orofacial movements, walking, and arousal (pupil diameter) of head-fixed mice performing a Go/NoGo visual detection task and examined the ability of task performance and spontaneous or task-related movements to predict cortical activity. A linear model was able to explain a significant fraction (33-55% of variance) of widefield dorsal cortical activity, with the largest factors being movements (facial, walk, eye), response choice (hit, miss, false alarm), and arousal and indicate that a significant fraction of trial-to-trial variability arises from both spontaneous and task-related changes in state (e.g., movements, arousal). Importantly, secondary motor cortex was highly correlated with lick rate, critical for optimal task performance (high d'), and was the first region to significantly predict the lick response on target trials. These findings suggest that secondary motor cortex is critically involved in the decision and performance of learned movements and indicate that a significant fraction of trial-to-trial variation in cortical activity results from spontaneous and task-related movements and variations in behavioral/arousal state.
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