Evidence map›Paper›PMID 31711099›Full record

ArticleAge and ageing2019

Protein intake and transitions between frailty states and to death in very old adults: the Newcastle 85+ study.

Nuno Mendonça, Andrew Kingston, Antoneta Granic, Carol Jagger

Abstract read
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In one paragraph

Article in Age and ageing, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  19. Development of Prognostic Prediction Model to Estimate Mortality for Frail Oldest Old: Prospective Cohort Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nuno MendonçaInstitute for Ageing, Faculty of Medical Sciences, Newcastle University, NE2 4AX, UK.
Andrew KingstonInstitute for Ageing, Faculty of Medical Sciences, Newcastle University, NE2 4AX, UK.
Antoneta GranicAGE Research Group, Institute of Neuroscience, Faculty of Medical Sciences, Newcastle University, NE2 4HH, UK.
Carol JaggerInstitute for Ageing, Faculty of Medical Sciences, Newcastle University, NE2 4AX, UK.

Funding

Biotechnology and Biological Sciences Research CouncilMedical Research Council G0500997Medical Research Council MR/J50001X/1
6 · The paper itself

Abstract

objectivesTo examine the association of protein intake with frailty progression in very old adults.

designThe Newcastle 85+ study, a prospective longitudinal study of people aged 85 years old in Northeast England and followed over 5 years. SETTING AND

participants668 community-dwelling older adults (59% women) at baseline, with complete dietary assessment and Fried frailty status (FFS). MEASURES: Dietary intake was estimated with 2 × 24-h multiple pass recalls at baseline. FFS was based on five criteria: shrinking, physical endurance/energy, low physical activity, weakness and slow walking speed and was available at baseline and 1.5, 3 and 5 years. The contribution of protein intake (g/kg adjusted body weight/day [g/kg aBW/d]) to transitions to and from FFS (robust, pre-frail and frail) and to death over 5 years was examined by multi-state models.

resultsIncrease in one unit of protein intake (g/kg aBW/d) decreased the likelihood of transitioning from pre-frail to frail after adjusting for age, sex, education and multimorbidity (hazard ratios [HR]: 0.44, 95% confidence interval [CI]: 0.25-0.77) but not for the other transitions. Reductions in incident frailty were equally present in individuals with protein intake ≥0.8 (HR: 0.60, 95% CI: 0.43-0.84) and ≥1 g/kg aBW/d (HR: 0.63, 95% CI: 0.44-0.90) from 85 to 90 years. This relationship was attenuated after adjustment for energy intake, but the direction of the association remained the same (e.g. g/kg aBW/d model: HR: 0.71, 95% CI: 0.36-1.41).

conclusionHigh protein intake, partly mediated by energy intake, may delay incident frailty in very old adults. Frailty prevention strategies in this age group should consider adequate provision of protein and energy.

Indexed as

Aged, 80 and overDietary ProteinsEnglandFemaleFrail ElderlyFrailtyHumansMaleRisk FactorsDietary Proteinsaged 80 and overfrailtyfriedmalnutritionmulti-state modelolder peoplePROMISSprotein

Identifiers

PMID31711099
PMCPMC6939283

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.