ArticleNeuroImage. Clinical2019
Brain iron content in systemic iron overload: A beta-thalassemia quantitative MRI study.
Article in NeuroImage. Clinical, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Surface-based brain age index reflects hematological impacts on cognitive development in children with beta-thalassemia major.iScience · 2026Article
- Brain Functional Connectivity as a Mediator Between Hematological Metrics and Cognitive Decline in Children With Beta-thalassemia Major.Brain and behavior · 2026Article
- Glymphatic dysfunction as an imaging biomarker for cognitive impairment in patients with β-thalassemia major: A multimodal MRI study.European journal of radiology open · 2025Article
- Cognitive impairment in hereditary spherocytosis.British journal of haematology · 2025Article
- Iron Deficiency Without Anemia and Reduced Basal Ganglia Iron Content in Youths.JAMA network open · 2025Article
- Study on Large-Scale Brain Network Abnormalities in Patients With Beta-Thalassemia.Brain and behavior · 2025Article
- White matter microstructure abnormalities in thalassemia patients using TBSS analysis based on DTI.Scientific reports · 2025Article
- Iron induces blood-brain barrier alteration contributing to cognitive impairment in β-thalassaemia mice.Scientific reports · 2025Article
- Brain perfusion changes in beta-thalassemia.Orphanet journal of rare diseases · 2024Article
- Cognitive impairment and hippocampal neuronal damage in β-thalassaemia mice.Scientific reports · 2024Article
- Oxidative Stress and Antioxidant Status in Adult Patients with Transfusion-Dependent Thalassemia: Correlation with Demographic, Laboratory, and Clinical Biomarkers.Antioxidants (Basel, Switzerland) · 2024Article
- Exploring experiences of mothers of children with thalassemia major in Indonesia: A descriptive phenomenological study.Belitung nursing journal · 2024Article
- Iron and Ferroptosis More than a Suspect: Beyond the Most Common Mechanisms of Neurodegeneration for New Therapeutic Approaches to Cognitive Decline and Dementia.International journal of molecular sciences · 2023Review
- Quantitative T2* MRI for bone marrow iron overload: normal reference values and assessment in thalassemia major patients.La Radiologia medica · 2022Article
- Article
- New Entity-Thalassemic Endocrine Disease: Major Beta-Thalassemia and Endocrine Involvement.Diagnostics (Basel, Switzerland) · 2022Review
- RANK/RANKL/OPG axis genes relation to cognitive impairment in children with transfusion-dependent thalassemia: a cross-sectional study.BMC pediatrics · 2022Article
- Neuroimaging Findings in Pediatric Patients with Thalassemia Major.Hematology reports · 2022Article
- Auditory cortex hypoperfusion: a metabolic hallmark in Beta Thalassemia.Orphanet journal of rare diseases · 2021Article
- Major Depression in Children with Transfusion-Dependent Thalassemia Is Strongly Associated with the Combined Effects of Blood Transfusion Rate, Iron Overload, and Increased Pro-inflammatory Cytokines.Neurotoxicity research · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveMultisystem iron poisoning is a major concern for long-term beta-thalassemia management. Quantitative MRI-based techniques routinely show iron overload in heart, liver, endocrine glands and kidneys. However, data on the brain are conflicting and monitoring of brain iron content is still matter of debate.
methodsThis 3T-MRI study applied a well validated high-resolution whole-brain quantitative MRI assessment of iron content on 47 transfusion-dependent (mean-age: 36.9 ± 10.3 years, 63% females), 23 non-transfusion dependent (mean-age: 29.2 ± 11.7 years, 56% females) and 57 healthy controls (mean-age: 33.9 ± 10.8 years, 65% females). Clinical data, Wechsler Adult Intelligence Scale scores and treatment regimens were recorded. Beside whole-brain R2* analyses, regional R2*-values were extracted in putamen, globus pallidum, caudate nucleus, thalamus and red nucleus; hippocampal volumes were also determined.
resultsRegional analyses yielded no significant differences between patients and controls, except in those treated with deferiprone that showed lower R2*-values (p<0.05). Whole-brain analyses of R2*-maps revealed strong age-R2* correlations (r
conclusionAccording to our MRI findings and the available histopathologic literature evidence, concerns about neural tissue iron overload in beta-thalassemia appear to be unjustified.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.