Evidence map›Paper›PMID 31710769›Full record

ArticleJournal of magnetic resonance imaging : JMRI2020

Deep-Learning-Based Preprocessing for Quantitative Myocardial Perfusion MRI.

Cian M Scannell, Mitko Veta, Adriana D M Villa, Eva C Sammut, Jack Lee, Marcel Breeuwer, Amedeo Chiribiri

Abstract read
In one paragraph

Article in Journal of magnetic resonance imaging : JMRI, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Society for cardiovascular magnetic resonance expert consensus statement on quantitative myocardial perfusion cardiovascular magnetic resonance imaging.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
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  11. Improved robustness for deep learning-based segmentation of multi-center myocardial perfusion cardiovascular MRI datasets using data-adaptive uncertainty-guided space-time analysis.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2024
    Article
  12. High-resolution quantification of stress perfusion defects by cardiac magnetic resonance.European heart journal. Imaging methods and practice · 2024
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  14. Temporal Uncertainty Localization to Enable Human-in-the-Loop Analysis of Dynamic Contrast-Enhanced Cardiac MRI Datasets.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Cian M ScannellSchool of Biomedical Engineering and Imaging Sciences, King's College London, UK.
Mitko VetaDepartment of Biomedical Engineering, Medical Image Analysis group, Eindhoven University of Technology, Eindhoven, The Netherlands.
Adriana D M VillaSchool of Biomedical Engineering and Imaging Sciences, King's College London, UK.
Eva C SammutSchool of Biomedical Engineering and Imaging Sciences, King's College London, UK.
Jack LeeSchool of Biomedical Engineering and Imaging Sciences, King's College London, UK.
Marcel BreeuwerDepartment of Biomedical Engineering, Medical Image Analysis group, Eindhoven University of Technology, Eindhoven, The Netherlands.
Amedeo ChiribiriSchool of Biomedical Engineering and Imaging Sciences, King's College London, UK.

Funding

The Wellcome Trust WT 088641/Z/09/Z
6 · The paper itself

Abstract

backgroundQuantitative myocardial perfusion cardiac MRI can provide a fast and robust assessment of myocardial perfusion status for the noninvasive diagnosis of myocardial ischemia while being more objective than visual assessment. However, it currently has limited use in clinical practice due to the challenging postprocessing required, particularly the segmentation. PURPOSE: To evaluate the efficacy of an automated deep learning (DL) pipeline for image processing prior to quantitative analysis. STUDY TYPE: Retrospective. POPULATION: In all, 175 (350 MRI scans; 1050 image series) clinical patients under both rest and stress conditions (135/10/30 training/validation/test). FIELD STRENGTH/SEQUENCE: 3.0T/2D multislice saturation recovery T ASSESSMENT: Accuracy was assessed, as compared to the manual operator, through the mean square error of the distance between landmarks and the Dice similarity coefficient of the segmentation and bounding box detection. Quantitative perfusion maps obtained using the automated DL-based processing were compared to the results obtained with the manually processed images. STATISTICAL TESTS: Bland-Altman plots and intraclass correlation coefficient (ICC) were used to assess the myocardial blood flow (MBF) obtained using the automated DL pipeline, as compared to values obtained by a manual operator.

resultsThe mean (SD) error in the detection of the time of peak signal enhancement in the left ventricle was 1.49 (1.4) timeframes. The mean (SD) Dice similarity coefficients for the bounding box and myocardial segmentation were 0.93 (0.03) and 0.80 (0.06), respectively. The mean (SD) error in the RV insertion point was 2.8 (1.8) mm. The Bland-Altman plots showed a bias of 2.6% of the mean MBF between the automated and manually processed MBF values on a per-myocardial segment basis. The ICC was 0.89, 95% confidence interval = [0.87, 0.90]. DATA

conclusionWe showed high accuracy, compared to manual processing, for the DL-based processing of myocardial perfusion data leading to quantitative values that are similar to those achieved with manual processing. LEVEL OF EVIDENCE: 3 Technical Efficacy Stage: 1 J. Magn. Reson. Imaging 2020;51:1689-1696.

Indexed as

Deep LearningHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingPerfusionRetrospective Studiesautomated image analysisconvolutional neural networksmachine learningquantitative myocardial perfusion

Identifiers

PMID31710769
PMCPMC7317373

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.