Evidence map›Paper›PMID 31710263›Full record

ArticleCell adhesion & migration2019

Paracrine signalling of AGR2 stimulates RhoA function in fibroblasts and modulates cell elongation and migration.

Hitesh Bhagavanbhai Mangukiya, Hema Negi, Siva Bharath Merugu, Qudsia Sehar, Dhahiri Saidi Mashausi, Fakhar-Un-Nisa Yunus, Zhenghua Wu, Dawei Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell adhesion & migration, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Construction and stable gene expression of AGR2xPD1 bi-specific antibody that enhances attachment betweenSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Hitesh Bhagavanbhai MangukiyaSchool of Pharmacy, Shanghai Jiao Tong University, Shanghai, China.ORCID 0000-0002-8460-4850
Hema NegiSchool of Pharmacy, Shanghai Jiao Tong University, Shanghai, China.
Siva Bharath MeruguSchool of Pharmacy, Shanghai Jiao Tong University, Shanghai, China.
Qudsia SeharSchool of Pharmacy, Shanghai Jiao Tong University, Shanghai, China.
Dhahiri Saidi MashausiSchool of Pharmacy, Shanghai Jiao Tong University, Shanghai, China.
Fakhar-Un-Nisa YunusSchool of Pharmacy, Shanghai Jiao Tong University, Shanghai, China.
Zhenghua WuSchool of Pharmacy, Shanghai Jiao Tong University, Shanghai, China.
Dawei LiSchool of Pharmacy, Shanghai Jiao Tong University, Shanghai, China.
Shanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The most prominent cancer-associated fibroblasts (CAFs) in tumor stroma is known to form a protective structure to support tumor growth. Anterior gradient-2 (AGR2), a tumor secretory protein is believed to play a pivotal role during tumor microenvironment (TME) development. Here, we report that extracellular AGR2 enhances fibroblasts elongation and migration significantly. The early stimulation of RhoA showed the association of AGR2 by upregulation of G1-S phase-regulatory protein cyclin D1 and FAK phosphorylation through fibroblasts growth factor receptor (FGFR) and vascular endothelial growth factor receptor (VEGFR). Our finding indicates that secretory AGR2 alters fibroblasts elongation, migration, and organization suggesting the secretory AGR2 as a potential molecular target that might be responsible to alter fibroblasts infiltration to support tumor growth.

Indexed as

3T3 CellsAnimalsCancer-Associated FibroblastsCell CycleCell Line, TumorCell MovementCell ProliferationCulture Media, ConditionedCyclin D1Focal Adhesion Kinase 1HumansMCF-7 CellsMiceMucoproteinsNeoplasmsOncogene ProteinsAgr2 protein, mouseCcnd1 protein, mouseCulture Media, ConditionedCyclin D1Fgfr1 protein, mouseFocal Adhesion Kinase 1MucoproteinsOncogene ProteinsPtk2 protein, mouseReceptor, Fibroblast Growth Factor, Type 1Receptors, Vascular Endothelial Growth FactorrhoA GTP-Binding ProteinRhoA protein, mouseAnterior gradient 2cell movementfibroblastsRhoA GTP-Binding ProteinTumour microenvironment

Identifiers

PMID31710263
PMCPMC6844563
OpenAlexW2986362498

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.