ArticleInternational journal of fertility & sterility2020
Relationship between Sperm Parameters with Sperm Function Tests in Infertile Men with at Least One Failed Cycle after Intracytoplasmic Sperm Injection Cycle.
Article in International journal of fertility & sterility, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07570342 (Comparison of Two Types of Calcium), which is not on this map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of Two Types of Calcium (Ca²⁺) Ionophore Treatments for Oocyte Activation in Cases of Suboptimal Fertilization Potential
Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Effect of CoQ10 Supplement on Spermogram Parameters and Sexual Function of Infertile Men Referred to The Infertility Center of Fatemieh Hospital, Hamadan, Iran, 2019: A Randomized Controlled Trial Study.International journal of fertility & sterility · 2023Article
- L-Carnitine and Pentoxifylline Supplementation Improves Sperm Viability and Motility at Low Temperature.International journal of fertility & sterility · 2023Article
- Relationship between sperm quality and total fertilization failure in intracytoplasmic sperm injection and in vitro fertilization cycles: A cross-sectional study.International journal of reproductive biomedicine · 2022Article
- Oocyte activation deficiency and assisted oocyte activation: mechanisms, obstacles and prospects for clinical application.Human reproduction open · 2022Review
- Current markers for infertility in men.JBRA assisted reproduction · 2021Article
- Protective effects of hesperetin on the quality of sperm, apoptosis, lipid peroxidation, and oxidative stress during the process of cryopreservation: An experimental study.International journal of reproductive biomedicine · 2021Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundImbalance between production of reactive oxygen species (ROS) and total antioxidant capacity in testis, epididymis, and seminal fluid can eventually lead to infertility. Abnormal sperm chromatin packaging, and DNA fragmentation is considered as the main underlying causes of infertility. Therefore, we aimed to assess relationship between sperm parameters with DNA damage, protamine deficiency, persistent histones, and lipid peroxidation in infertile men with at least one failed cycle after intracytoplasmic sperm injection (ICSI). MATERIALS AND
methodsIn this experimental study, semen samples were collected from infertile men with at least one failed cycle after ICSI (n=20). Sperm parameters, DNA damage, protamine deficiency, persistent histones, and lipid peroxidation were assessed using computer-assisted sperm analysis (CASA) system, sperm chromatin structure assay (SCSA) and Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assays, chromomycin A3, aniline blue, and BODIPY C11 staining, respectively.
resultsA negative significant correlation was observed between sperm concentration with percentage of sperm persistent histone (r=-0.56, P=0.02), while positive significant correlations were found between percentage of sperm persistent histones with abnormal sperm morphology (r=0.54, P=0.02), CMA3-positive spermatozoa (r=0.6, P=0.008) and intensity of lipid peroxidation (r=0.6, P=0.01). In addition, a significant correlation was observed between sperm DNA damage with intensity and percentage of lipid peroxidation (r=0.62, P=0.009, r=0.77, P=0.007). Correlation between CMA3-positive spermatozoa and intensity of lipid peroxidation (r=0.5, P=0.03) were also significant.
conclusionObserved significant correlations between sperm functional tests in infertile men with at least one failed cycle after ICSI, indicated that the reduction of oxidative stress by antioxidant supplementation may be considered as one therapy approach for improvement of sperm function and increase the chance of successful clinical outcomes in next assisted reproductive cycle.
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