ArticleInternational journal of fertility & sterility2020
Dietary Phytoestrogen Intake and The Risk of Endometriosis in Iranian Women: A Case-Control Study.
Article in International journal of fertility & sterility, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Food groups and nutrients consumption and risk of endometriosis: a systematic review and meta-analysis of observational studies.Nutrition journal · 2022Pooled it
- Effectiveness of Dietary Interventions in the Treatment of Endometriosis: a Systematic Review.Reproductive sciences (Thousand Oaks, Calif.) · 2022Pooled it
- Pooled it
- The Role of Nutrition on the Pathogenesis of Endometriosis.Nutrients · 2026Review
- Nutrition and Endometriosis: Current Evidence on Dietary Risk Factors and Clinical Impact - A Narrative Review.Journal of inflammation research · 2026Review
- The effect of phytoestrogens and PAHs on endometriosis and the involvement of gut microbiota, inflammation, and molecular targets.Scientific reports · 2025Article
- Effectiveness of Medical Nutrition Therapy in the Management of Patients with Obesity and Endometriosis: from the Mediterranean Diet To the Ketogenic Diet, Through Supplementation. The Role of the Nutritionist in Clinical Management.Current obesity reports · 2025Review
- Endometriosis and Nutrition: Therapeutic Perspectives.Journal of clinical medicine · 2025Review
- Exploring the Association Between Dietary Fruit Intake and Endometriosis: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- Phytoestrogens: A Promising Therapeutic Approach for Endometriosis Management, Insights from Preclinical and Clinical Studies.Current pharmaceutical design · 2025Review
- Effects of a traditionally preparedFrontiers in nutrition · 2025Article
- Role of macronutrients, dairy products, fruits and vegetables in occurrence and progression of endometriosis: A summary of current evidence in a systematic review.Facts, views & vision in ObGyn · 2024Article
- Low Diet Quality and Nutritional Knowledge in Women with Endometriosis: A Pilot Study.Healthcare (Basel, Switzerland) · 2024Article
- Diet in Prevention and Treatment of Endometriosis: Current State of Knowledge.Current nutrition reports · 2024Review
- Insight into the Potential Mechanisms of Endocrine Disruption by Dietary Phytoestrogens in the Context of the Etiopathogenesis of Endometriosis.International journal of molecular sciences · 2023Review
- The relationship between dietary micronutrients and endometriosis: A case-control study.International journal of reproductive biomedicine · 2023Article
- New concepts on the etiology of endometriosis.The journal of obstetrics and gynaecology research · 2023Article
- I Am the 1 in 10-What Should I Eat? A Research Review of Nutrition in Endometriosis.Nutrients · 2022Review
- Female infertility and herbal medicine: An overview of the new findings.Food science & nutrition · 2021Review
- Phytoestrogens for the Management of Endometriosis: Findings and Issues.Pharmaceuticals (Basel, Switzerland) · 2021Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEndometriosis is an important gynecologic disease affecting reproductive-age women. Based on the effect of phytoestrogens on inflammatory, immunological and hormonal factors, limited studies have suggested that phytoestrogen consumption could probably modulate endometriosis risk. The aim of this study was to evaluate the relationship between phytoestrogen intake and endometriosis risk. MATERIALS AND
methodsIn the present case-control study, 78 women with a laparoscopically confirmed endometriosis and 78 normal pelvis women (as the control group), were recruited. Common dietary intake was recorded by a validated 147-item semi-quantitative food frequency questionnaire (FFQ). Type of phytoestrogen in each dietary item was analyzed by the database from the United States Department of Agriculture (USDA). A logistic regression model was used to determine the association between phytoestrogen intake and endometriosis risk.
resultsHigher intake of total phytoestrogen (P-trend=0.01), total isoflavones (P-trend=0.002) specially formononetin (P-trend=0.04) and glycitein (P-trend=0.04), total lignan (P-trend=0.01) specially secoisolariciresinol (P-trend=0.01) and lariciresinol (P-trend=0.02) and matairesinol (P-trend=0.003), and total coumestrol [third quartile odds ratios (OR): 0.38; 95% confidence intervals (CI): 0.15-0.96; P-trend=0.1] was related to reduced endometriosis risk. Among food groups, only isoflavin (OR: 0.48; 95% CI: 0.44-0.63), lignan (OR: 0.66; 95% CI: 0.62-0.94), coumestrol (OR: 0.64; 95% CI: 0.51-0.99), phytoestrogen (OR: 0.46; 95% CI: 0.38-0.83) in dairy products and coumestrol in fruits (OR: 0.69; 95% CI: 0.03-0.77) were negatively associated with endometriosis risk.
conclusionPhytoestrogens have a major impact on the level of hormones, and immune and inflammatory markers; thus, it can play an important role in the control and prevention of many diseases. Due to the inflammatory nature of endometriosis and the effect of hormones on the progression of the disease, the role of phytoestrogens consumption in the progression and regression of the disease should be assessed in future works.
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Registered trials
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