Evidence map›Paper›PMID 31709896›Full record

ArticleCancer biology & therapy2020

Botryllamide G is an ABCG2 inhibitor that improves lapatinib delivery in mouse brain.

Jonathan D Strope, Cody J Peer, Tristan M Sissung, O Morgan Hall, Phoebe A Huang, Emily M Harris, Kirk R Gustafson, Curtis J Henrich, Dina M Sigano, Gary T Pauly and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer biology & therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Roles of the ABCG2 Transporter in Protoporphyrin IX Distribution and Toxicity.Drug metabolism and disposition: the biological fate of chemicals · 2024
    Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Jonathan D StropeMolecular Pharmacology Section, National Cancer Institute, Bethesda, MD, USA.
Cody J PeerClinical Pharmacology Program, National Cancer Institute, Bethesda, MD, USA.
Tristan M SissungClinical Pharmacology Program, National Cancer Institute, Bethesda, MD, USA.
O Morgan HallClinical Pharmacology Program, National Cancer Institute, Bethesda, MD, USA.
Phoebe A HuangMolecular Pharmacology Section, National Cancer Institute, Bethesda, MD, USA.
Emily M HarrisMolecular Pharmacology Section, National Cancer Institute, Bethesda, MD, USA.
Kirk R GustafsonMolecular Targets Program, National Cancer Institute, Frederick, MD, USA.
Curtis J HenrichMolecular Targets Program, National Cancer Institute, Frederick, MD, USA.
Dina M SiganoChemical Biology Laboratory, National Cancer Institute, Frederick, MD, USA.
Gary T PaulyChemical Biology Laboratory, National Cancer Institute, Frederick, MD, USA.
Joel P SchneiderChemical Biology Laboratory, National Cancer Institute, Frederick, MD, USA.
Susan E BatesDepartment of Medicine, Division of Hematology and Oncology, Columbia University, New York, NY, USA.
William D FiggMolecular Pharmacology Section, National Cancer Institute, Bethesda, MD, USA.
National Cancer Institute · USColumbia University · USFrederick National Laboratory for Cancer Research · US

Funding

Natural Products Discovery and Characterization Through Network CollaborationsZIABC011568 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI DU, LIN · 2014 to 2025
$17.2M
Using Clinical Pharmacology Principles to Develop New Anticancer TherapiesZICSC006537 · NCI · DIVISION OF CLINICAL SCIENCES - NCI · PI FIGG, WILLIAM DOUGLAS · 2009 to 2025
$14.4M
Chemical Synthesis GroupZICBC011515 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI SCHNEIDER, JOEL · 2013 to 2025
$5.1M
Intramural NIH HHS ZIC SC006537
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AcrylamidesAnimalsAntineoplastic AgentsATP-Binding Cassette Sub-Family B Member 4ATP Binding Cassette Transporter, Subfamily BATP Binding Cassette Transporter, Subfamily B, Member 1ATP Binding Cassette Transporter, Subfamily G, Member 2Blood-Brain BarrierBrainLapatinibMaleMiceMice, KnockoutPhenolsTissue DistributionAbcg2 protein, mouseAcrylamidesAntineoplastic AgentsATP-Binding Cassette Sub-Family B Member 4ATP Binding Cassette Transporter, Subfamily BATP Binding Cassette Transporter, Subfamily B, Member 1ATP Binding Cassette Transporter, Subfamily G, Member 2botryllamide GLapatinibmultidrug resistance protein 3PhenolsABCB1ABCG2blood brain barrierBotryllamide Glapatinib

Identifiers

PMID31709896
PMCPMC7012088
OpenAlexW2986897923

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.