Evidence map›Paper›PMID 31709830›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2020

CD8

Denitra A Breuer, Maria Cristina Pacheco, M Kay Washington, Stephanie A Montgomery, Alyssa H Hasty, Arion J Kennedy

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 1 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 1 synthesis or guideline pooled it, 106 citations in OpenAlex.

  1. Pooled it
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  19. IL-15-Activated CD38Scientific reports · 2025
    Article
  20. Review

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Denitra A BreuerDepartment of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, North Carolina.
Maria Cristina PachecoDepartment of Pathology, Microbiology & Immunology, Vanderbilt University Medical Center, Nashville, Tennessee.
M Kay WashingtonDepartment of Pathology, Microbiology & Immunology, Vanderbilt University Medical Center, Nashville, Tennessee.
Stephanie A MontgomeryDepartment of Pathology and Laboratory Medicine and Lineberger Cancer Center, University North Carolina Chapel Hill, Chapel Hill, North Carolina.
Alyssa H HastyDepartment of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee.ORCID 0000-0001-7302-8045
Arion J KennedyDepartment of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, North Carolina.
Vanderbilt University Medical Center · USNorth Carolina State University · USUniversity of North Carolina at Chapel Hill · US

Funding

The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9M
The Role of CD8+ T Cells In The Development of Nonalcoholic Fatty Liver DiseaseK01HL121010 · NHLBI · VANDERBILT UNIVERSITY · PI KENNEDY, ARION · 2014 to 2018
$565k
NCATS NIH HHS UL1 TR000445NHLBI NIH HHS K01 HL121010NIDDK NIH HHS P30 DK058404
6 · The paper itself

Abstract

Nonalcoholic steatohepatitis (NASH) has increased in Western countries due to the prevalence of obesity. Current interests are aimed at identifying the type and function of immune cells that infiltrate the liver and key factors responsible for mediating their recruitment and activation in NASH. We investigated the function and phenotype of CD8

Indexed as

AnimalsCD8-Positive T-LymphocytesHepatic Stellate CellsHepatitisHumansHyperlipidemiasInterleukin-10LiverMaleMiceMice, Inbred C57BLMice, ObeseNon-alcoholic Fatty Liver DiseaseObesityReceptors, LDLIL10 protein, humanIL10 protein, mouseInterleukin-10Receptors, LDLCD8+ T cellslymphocytesnonalcoholic steatohepatitisstellate cells

Identifiers

PMID31709830
PMCPMC7052570
OpenAlexW2987745771

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.