Evidence map›Paper›PMID 31709777›Full record

Trial reportAnnals of clinical and translational neurology2019

Safety of slow-pulsed transcranial electrical stimulation in acute spike suppression.

Mark D Holmes, Rui Feng, Mackenzie V Wise, Chengxin Ma, Ceon Ramon, Jinsong Wu, Phan Luu, Jidong Hou, Li Pan, Don M Tucker

Open access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Annals of clinical and translational neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Mark D HolmesRegional Epilepsy Center, Department of Neurology, University of Washington, Seattle, Washington.ORCID 0000-0001-6621-2848
Rui FengDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
Mackenzie V WiseRegional Epilepsy Center, Department of Neurology, University of Washington, Seattle, Washington.
Chengxin MaDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
Ceon RamonRegional Epilepsy Center, Department of Neurology, University of Washington, Seattle, Washington.
Jinsong WuDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
Phan LuuBrain Electrophysiology Laboratory Company, Eugene, Oregon.
Jidong HouSleepIQ Labs, San Jose, California.
Li PanDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
Don M TuckerBrain Electrophysiology Laboratory Company, Eugene, Oregon.
Fudan University · CNUniversity of Washington · USUniversity of Oregon · USSpectral Labs (United States) · US

Funding

Electrical Geodesics, Inc.
6 · The paper itself

Abstract

We examined the effects of slow-pulsed transcranial electrical stimulation (TES) in suppressing epileptiform discharges in seven adults with refractory epilepsy. An MRI-based realistic head model was constructed for each subject and co-registered with 256-channel dense EEG (dEEG). Interictal spikes were localized, and TES targeted the cortical source of each subject's principal spike population. Targeted spikes were suppressed in five subject's (29/35 treatment days overall), and nontargeted spikes were suppressed in four subjects. Epileptiform activity did not worsen. This study suggests that this protocol, designed to induce long-term depression (LTD), is safe and effective in acute suppression of interictal epileptiform discharges.

Indexed as

ElectroencephalographyElectrophysiological PhenomenaAdultDrug Resistant EpilepsyFemaleHumansMaleMiddle AgedProcess Assessment, Health CareTranscranial Direct Current StimulationYoung Adult

Identifiers

PMID31709777
PMCPMC6917336
OpenAlexW2988577539

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.