Evidence map›Paper›PMID 31709622›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2019

A "Missile-Detonation" Strategy to Precisely Supply and Efficiently Amplify Cerenkov Radiation Energy for Cancer Theranostics.

Bo Yu, Dalong Ni, Zachary T Rosenkrans, Todd E Barnhart, Hao Wei, Carolina A Ferreira, Xiaoli Lan, Jonathan W Engle, Qianjun He, Faquan Yu and 1 more

Abstract read
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Selenium Nanoparticles Selectively Target KRAS G13D to Inhibit Colorectal Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
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  12. Intraoperative fluorescence molecular imaging accelerates the coming of precision surgery in China.European journal of nuclear medicine and molecular imaging · 2022
    Review
  13. Article
  14. Article
  15. High relaxivity GdJournal of nanobiotechnology · 2022
    Article
  16. Light-Sensitive Phenacyl Crosslinked Dextran Hydrogels for Controlled Delivery.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022
    Article
  17. Review
  18. Review
  19. Solutions to the Drawbacks of Photothermal and Photodynamic Cancer Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Bo YuNational-Regional Key Technology Engineering Laboratory for Medical Ultrasound, Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, 518060, China.
Dalong NiDepartments of Radiology and Medical Physics, University of Wisconsin-Madison, Madison, WI, 53705, USA.
Zachary T RosenkransDepartments of Radiology and Medical Physics, University of Wisconsin-Madison, Madison, WI, 53705, USA.
Todd E BarnhartDepartments of Radiology and Medical Physics, University of Wisconsin-Madison, Madison, WI, 53705, USA.
Hao WeiDepartments of Radiology and Medical Physics, University of Wisconsin-Madison, Madison, WI, 53705, USA.
Carolina A FerreiraDepartments of Radiology and Medical Physics, University of Wisconsin-Madison, Madison, WI, 53705, USA.
Xiaoli LanDepartment of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430073, China.
Jonathan W EngleDepartments of Radiology and Medical Physics, University of Wisconsin-Madison, Madison, WI, 53705, USA.
Qianjun HeNational-Regional Key Technology Engineering Laboratory for Medical Ultrasound, Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, 518060, China.
Faquan YuKey Laboratory for Green Chemical Process of Ministry of Education, School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan, 430073, China.
Weibo CaiDepartments of Radiology and Medical Physics, University of Wisconsin-Madison, Madison, WI, 53705, USA.ORCID https://orcid.org/0000-0003-4641-0833

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Christian Capitini · 1985 to 2026
$142.6M
Brazilian Science without Borders Program SwB-CNPqNational Institutes of Health P30CA014520National Natural Science Foundation of China 21571147National Natural Science Foundation of China 81601605Natural Science Foundation of SZU 827-000143NCI NIH HHS P30 CA014520NIH HHS P30CA014520Postdoctoral Science Foundation of China 2016M600670Shenzhen Basic Research Program JCYJ20170302151858466Shenzhen Peacock Plan KQTD2016053112051497University of Wisconsin-Madison
6 · The paper itself

Abstract

Cerenkov radiation (CR) from radionuclides can act as a built-in light source for cancer theranostics, opening a new horizon in biomedical applications. However, considerably low tumor-targeting efficiency of existing radionuclides and radionuclide-based nanomedicines limits the efficacy of CR-induced theranostics (CRIT). It remains a challenge to precisely and efficiently supply CR energy to the tumor site. Here, a "missile-detonation" strategy is reported, in which a high dose of p-SCN-Bn-deferoxamine-porphyrin-PEG nanocomplex (Df-PPN) is first adminstered as a CR energy receiver/missile to passively target to tumor, and then a low dose of the

Indexed as

Theranostic NanomedicineAnimalsCell Line, TumorDeferoxamineEnergy TransferHumansMiceMice, Inbred BALB CNanostructuresNeoplasmsNeovascularization, PathologicOxidative StressPhotochemotherapyPhotosensitizing AgentsPolyethylene GlycolsPorphyrinsDeferoxaminePhotosensitizing AgentsPolyethylene GlycolsPorphyrinsRadioisotopesZirconiumZirconium-89cancer theranosticsCerenkov radiationmultimodal imagingpositron emission tomographytargeted drug delivery

Identifiers

PMID31709622
PMCPMC6928399

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.