Evidence map›Paper›PMID 31709475›Full record

ArticleJournal of neurology2020

Detailed phenotyping of posterior vs. anterior circulation ischemic stroke: a multi-center MRI study.

Petrea Frid, Mattias Drake, A K Giese, J Wasselius, M D Schirmer, K L Donahue, L Cloonan, R Irie, M J R J Bouts, E C McIntosh and 34 more

Open access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 43 citations in OpenAlex.

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  14. Posterior circulation ischaemic stroke diagnosis and management.Clinical medicine (London, England) · 2023
    Review
  15. Migraine-Associated Common Genetic Variants Confer Greater Risk of Posterior vs. Anterior Circulation Ischemic Stroke☆.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

44 authors at 16 institutions in 10 countries.

Petrea FridDepartment of Clinical Sciences Lund, Neurology, Lund University, Lund, Sweden. petrea.frid@med.lu.se.ORCID http://orcid.org/0000-0003-1452-2064
Mattias DrakeDepartment of Clinical Sciences Lund, Radiology, Lund University, Lund, Sweden.
A K GieseJ. Philip Kistler Stroke Research Center, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
J WasseliusDepartment of Clinical Sciences Lund, Radiology, Lund University, Lund, Sweden.
M D SchirmerJ. Philip Kistler Stroke Research Center, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
K L DonahueJ. Philip Kistler Stroke Research Center, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
L CloonanJ. Philip Kistler Stroke Research Center, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
R IrieDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital (MGH), Harvard Medical School, Charlestown, MA, USA.
M J R J BoutsDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital (MGH), Harvard Medical School, Charlestown, MA, USA.
E C McIntoshDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital (MGH), Harvard Medical School, Charlestown, MA, USA.
S J T MockingDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital (MGH), Harvard Medical School, Charlestown, MA, USA.
A V DalcaComputer Science and Artificial Intelligence Laboratory, MIT, Cambridge, USA.
R SridharanComputer Science and Artificial Intelligence Laboratory, MIT, Cambridge, USA.
H XuDivision of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
E Giralt-SteinhauerNeurovascular Research Group (NEUVAS), Department of Neurology, IMIM-Hospital del Mar (Institut Hospital del Mar d'Investigacions Mèdiques), Universitat Autonoma de Barcelona, Barcelona, Spain.
L HolmegaardDepartment of Clinical Neuroscience, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
K JoodDepartment of Clinical Neuroscience, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
J RoquerNeurovascular Research Group (NEUVAS), Department of Neurology, IMIM-Hospital del Mar (Institut Hospital del Mar d'Investigacions Mèdiques), Universitat Autonoma de Barcelona, Barcelona, Spain.
J W ColeDepartment of Neurology, University of Maryland School of Medicine and Veterans Affairs Maryland Health Care System, Baltimore, MD, USA.
P F McArdleDivision of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
J P BroderickDepartment of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
J Jimenez-CondeNeurovascular Research Group (NEUVAS), Department of Neurology, IMIM-Hospital del Mar (Institut Hospital del Mar d'Investigacions Mèdiques), Universitat Autonoma de Barcelona, Barcelona, Spain.
C JernInstitute of Biomedicine, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
B M KisselaDepartment of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
D O KleindorferDepartment of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
R LemmensDepartment of Neurosciences, Experimental Neurology, KU Leuven-University of Leuven, Louvain, Belgium.
J F MeschiaDepartment of Neurology, Mayo Clinic, Jacksonville, FL, USA.
T RundekDepartment of Neurology and Evelyn F. McKnight Brain Institute, Miller School of Medicine, University of Miami, Miami, FL, USA.
R L SaccoDepartment of Neurology and Evelyn F. McKnight Brain Institute, Miller School of Medicine, University of Miami, Miami, FL, USA.
R SchmidtClinical Division of Neurogeriatrics, Department of Neurology, Medical University Graz, Graz, Austria.
P SharmaInstitute of Cardiovascular Research, Royal Holloway University of London (ICR2UL), Egham, UK.
A SlowikDepartment of Neurology, Jagiellonian University Medical College, Kraków, Poland.
V ThijsStroke Division, Florey Institute of Neuroscience and Mental Health, Heidelberg, Australia.
D WooDepartment of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
B B WorrallDepartment of Neurology, University of Virginia, Charlottesville, VA, USA.
S J KittnerDepartment of Neurology, University of Maryland School of Medicine and Veterans Affairs Maryland Health Care System, Baltimore, MD, USA.
B D MitchellDivision of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
J PeterssonDepartment of Clinical Sciences Lund, Neurology, Lund University, Lund, Sweden.
J RosandJ. Philip Kistler Stroke Research Center, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
P GollandComputer Science and Artificial Intelligence Laboratory, MIT, Cambridge, USA.
O WuDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital (MGH), Harvard Medical School, Charlestown, MA, USA.
N S RostJ. Philip Kistler Stroke Research Center, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
A LindgrenDepartment of Clinical Sciences Lund, Neurology, Lund University, Lund, Sweden.
Stroke Genetics Network (SiGN), the International Stroke Genetics Consortium (ISGC), and the MRI-Genetics Interface Exploration (MRI-GENIE) Study
Harvard University · USLund University · SEUniversity of Maryland, Baltimore · USUniversity of Cincinnati Medical Center · USUniversitat Autònoma de Barcelona · ESBroad Institute · USSahlgrenska University Hospital · SEUniversity of Miami · USFlorey Institute of Neuroscience and Mental Health · AUJagiellonian University · PLMedical University of Graz · ATRoyal Holloway University of London · GBUniversity of Gothenburg · SEUniversity of Virginia · USVIB-KU Leuven Center for Brain & Disease Research · BEWinnMed · US

Funding

CREST-2 Clinical Coordinating CenterU01NS080168 · NINDS · MAYO CLINIC JACKSONVILLE · PI Thomas G Brott, JAMES F MESCHIA · 2014 to 2026
$56.3M
Training and DisseminationP41EB015902 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI KIKINIS, RON, WESTIN, CARL-FREDRIK · 2012 to 2022
$20.9M
Research BaseP30DK072488 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI MITCHELL, BRAXTON D, TAYLOR, SIMEON I. · 2005 to 2019
$17.3M
The NINDS International Stroke Genetics Consortium StudyU01NS069208 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI KITTNER, STEVEN J · 2010 to 2013
$9.4M
MRI-GENetics Interface Exploration_MRI-GENIE_StudyR01NS086905 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI ROST, NATALIA S · 2015 to 2019
$3.3M
Genetics of ischemic stroke in the SiGN ConsortiumR01NS100178 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI KITTNER, STEVEN J, MITCHELL, BRAXTON D · 2017 to 2021
$3.0M
Genetics of Early-Onset Ischemic Stroke ConsortiumR01NS105150 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI KITTNER, STEVEN J, MITCHELL, BRAXTON D · 2018 to 2022
$3.0M
NIBIB NIH HHS P41 EB015902NIBIB NIH HHS P41EB015902NIDDK NIH HHS P30 DK072488NINDS NIH HHS NINDS U01 NS080168NINDS NIH HHS R01 NS086905NINDS NIH HHS R01NS086905NINDS NIH HHS R01 NS100178NINDS NIH HHS R01NS100178NINDS NIH HHS R01 NS105150NINDS NIH HHS R01NS105150NINDS NIH HHS U01 NS069208NINDS NIH HHS U01 NS080168
6 · The paper itself

Abstract

objectivePosterior circulation ischemic stroke (PCiS) constitutes 20-30% of ischemic stroke cases. Detailed information about differences between PCiS and anterior circulation ischemic stroke (ACiS) remains scarce. Such information might guide clinical decision making and prevention strategies. We studied risk factors and ischemic stroke subtypes in PCiS vs. ACiS and lesion location on magnetic resonance imaging (MRI) in PCiS.

methodsOut of 3,301 MRIs from 12 sites in the National Institute of Neurological Disorders and Stroke (NINDS) Stroke Genetics Network (SiGN), we included 2,381 cases with acute DWI lesions. The definition of ACiS or PCiS was based on lesion location. We compared the groups using Chi-squared and logistic regression.

resultsPCiS occurred in 718 (30%) patients and ACiS in 1663 (70%). Diabetes and male sex were more common in PCiS vs. ACiS (diabetes 27% vs. 23%, p < 0.05; male sex 68% vs. 58%, p < 0.001). Both were independently associated with PCiS (diabetes, OR = 1.29; 95% CI 1.04-1.61; male sex, OR = 1.46; 95% CI 1.21-1.78). ACiS more commonly had large artery atherosclerosis (25% vs. 20%, p < 0.01) and cardioembolic mechanisms (17% vs. 11%, p < 0.001) compared to PCiS. Small artery occlusion was more common in PCiS vs. ACiS (20% vs. 14%, p < 0.001). Small artery occlusion accounted for 47% of solitary brainstem infarctions.

conclusionIschemic stroke subtypes differ between the two phenotypes. Diabetes and male sex have a stronger association with PCiS than ACiS. Definitive MRI-based PCiS diagnosis aids etiological investigation and contributes additional insights into specific risk factors and mechanisms of injury in PCiS.

Indexed as

AgedArterial Occlusive DiseasesBasilar ArteryCerebral Arterial DiseasesFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNeuroimagingPhenotypeStrokeVertebral ArteryVertebrobasilar InsufficiencyMagnetic resonance imagingPhenotypingPosterior circulation brain infarctionRisk factorsStroke

Identifiers

PMID31709475
PMCPMC7035231
OpenAlexW2987647138

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.