ArticleEClinicalMedicine2019
Pregnancy Loss and Cancer Risk: A Nationwide Observational Study.
Article in EClinicalMedicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Fetal loss and long-term maternal morbidity and mortality: A systematic review and meta-analysis.PLoS medicine · 2024Pooled it
- Induced abortion, miscarriage, and the risk of breast cancer-A registry-based study from Finland.Acta obstetricia et gynecologica Scandinavica · 2026Article
- Worse prognosis for breast cancer diagnosed in advanced pregnancy and shortly postpartum: an update of the Dutch pregnancy-associated breast cancer cohort.Breast cancer research and treatment · 2025Article
- Clinical Prognostic Factors for Overall Survival in Patients Undergoing Radical Radiotherapy for Cervical Cancer.International journal of women's health · 2025Article
- Risk factors associated with pregnancy loss after single euploid blastocysts transfer.Frontiers in endocrinology · 2024Article
- Pregnancy Loss in Relation to the Risks of Female-Specific Cancers in a Population-Based Cohort and Mendelian Randomization Study - China, 2004-2017.China CDC weekly · 2023Article
- Risk of Gynecological Cancers in Women With Polycystic Ovary Syndrome and the Pathophysiology of Association.Cureus · 2023Review
- Abortion and Female Cancer Risks among Women Aged 20 to 45 Years: A 10-Year Longitudinal Population-Based Cohort Study in Taiwan.International journal of environmental research and public health · 2023Observational
- Review
- Different Background: Natural Killer Cell Profiles in Secondary versus Primary Recurrent Pregnancy Loss.Journal of clinical medicine · 2021Article
- Phenome-Wide Analysis of Short- and Long-Run Disease Incidence Following Recurrent Pregnancy Loss Using Data From a 39-Year Period.Journal of the American Heart Association · 2020Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCancer is the second leading cause of death worldwide. Few studies have investigated if recurrent pregnancy loss is associated with an increased risk of cancer. We aimed to assess whether pregnancy loss is associated with later cancer development.
methodsWe identified all invasive cancers after age 40, among all Danish women born between January 1957 and December 1972, ensuring a full reproductive history. Cases were matched by birth year 1:10 to cancer-free controls. Women were followed until the end of 2017. The number of pregnancy losses (miscarriages or still births) was correlated to long-term cancer risk using conditional logistic regression, providing odds ratios for specific cancers with different numbers of pregnancy losses, all adjusted for age, education, and other potential confounders.
findingsThe study included 28,785 women with cancer (mean age 48.7 [SD 5.0]) and 283,294 matched controls (mean age 48.6 [SD 5.0]). We found no overall association between pregnancy loss and later development of 11 site-specific types of cancer or cancer overall. Taking the sequence of pregnancy losses into account, primary recurrent pregnancy loss (three consecutive pregnancy losses without prior live birth) was associated with later overall cancer by an odds ratio of 1.27 (1.04-1.56). Secondary recurrent pregnancy loss showed no association to cancer.
interpretationPregnancy loss was not associated with later cancer development. Women with primary recurrent pregnancy loss had a borderline significant association to later cancer overall, this may be a chance finding.
fundingOle Kirk's Foundation and Copenhagen University Hospital Rigshospitalet's Research Grant.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.