ArticleJACC. Basic to translational science2019
Acute Kidney Injury Induces Remote Cardiac Damage and Dysfunction Through the Galectin-3 Pathway.
Article in JACC. Basic to translational science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 72 citations in OpenAlex.
- Absence of Kidney Tubular Injury in Patients With Acute Heart Failure With Acute Kidney Injury.Circulation. Heart failure · 2024Trial
- Early postoperative galectin-3 for risk stratification of delayed graft function after kidney transplantation.Clinical kidney journal · 2026Article
- AKI as a systemic syndrome and its impact on other organ systems.Critical care (London, England) · 2026Review
- Experimental rodent models of cardiorenal syndrome types 3 and 4: Insights and clinical relevance (Review).International journal of molecular medicine · 2026Review
- Galectin-3 in AKI: Pathogenic Target, Diagnostic Biomarker, or Both?International journal of biological sciences · 2026Article
- Burns: The "Fuse" That Ignites Organ Crisis - A Narrative Review of Mechanisms and Crosstalk in Post-Burn MODS.Journal of inflammation research · 2026Review
- Kidney-organ interactions: recent advances and clinical implications.Current opinion in critical care · 2025Review
- Galectin-3/CD146 interaction promotes renal damage and systemic inflammation after acute kidney injury.Scientific reports · 2025Article
- Galectin-3 Is Associated With Risk of Cardiovascular and Kidney Outcomes in Ambulatory Veterans.Kidney medicine · 2025Article
- Worsening Renal Function in Acute Heart Failure: Not Always Harmful.Current heart failure reports · 2025Review
- Transcoronary study of biomarkers in patients with heart failure: Insights into intracardiac production.ESC heart failure · 2025Article
- Endogenous Galectin-8 protects against Th17 infiltration and fibrosis following acute kidney injury.Molecular medicine (Cambridge, Mass.) · 2025Article
- Chronic changes developing in the hydronephrotic and contralateral kidneys during unilateral ureteral obstruction in rats.Molecular biology reports · 2025Article
- From Risk Assessment to Management: Cardiovascular Complications in Pre- and Post-Kidney Transplant Recipients: A Narrative Review.Diagnostics (Basel, Switzerland) · 2025Review
- The KLF4/Galectin-3 cascade is a key determinant of tubular cell death and acute kidney injury.International journal of biological sciences · 2025Article
- Endothelial-specific deletion of connexin 43 improves renal function and structure after acute kidney injury.Molecular medicine (Cambridge, Mass.) · 2024Article
- Acute kidney injury as a key predictor of cardiovascular events in chronic kidney disease patients: the CKD-REIN study.Clinical kidney journal · 2024Article
- Acute kidney disease in mice is associated with early cardiovascular dysfunction.Renal failure · 2024Article
- Review
- The Possible Effects of Galectin-3 on Mechanisms of Renal and Hepatocellular Injury Induced by Intravascular Hemolysis.International journal of molecular sciences · 2024Review
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Authors and funding
19 authors at 10 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute kidney injury is associated with increased risk of heart failure and mortality. This study demonstrates that acute kidney injury induces remote cardiac dysfunction, damage, injury, and fibrosis via a galectin-3 (Gal-3) dependent pathway. Gal-3 originates from bone marrow-derived immune cells. Cardiac damage could be prevented by blocking this pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.