Evidence map›Paper›PMID 31709223›Full record

ArticleFrontiers in chemistry2019

Targeted High Resolution LC/MS

Andrea Carrà, Valeria Guidolin, Romel P Dator, Pramod Upadhyaya, Fekadu Kassie, Peter W Villalta, Silvia Balbo

Open access · goldAbstract read
In one paragraph

Article in Frontiers in chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 37 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. A Novel Adductomics Workflow IncorporatingEnvironmental science & technology · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. LC-MSMolecules (Basel, Switzerland) · 2022
    Article
  14. A Comprehensive Database for DNA Adductomics.Frontiers in chemistry · 2022
    Article
  15. Molecular Damage in Aging.Nature aging · 2021
    Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Andrea CarràMasonic Cancer Center, University of Minnesota, Minneapolis, MN, United States.
Valeria GuidolinMasonic Cancer Center, University of Minnesota, Minneapolis, MN, United States.
Romel P DatorMasonic Cancer Center, University of Minnesota, Minneapolis, MN, United States.
Pramod UpadhyayaMasonic Cancer Center, University of Minnesota, Minneapolis, MN, United States.
Fekadu KassieMasonic Cancer Center, University of Minnesota, Minneapolis, MN, United States.
Peter W VillaltaMasonic Cancer Center, University of Minnesota, Minneapolis, MN, United States.
Silvia BalboMasonic Cancer Center, University of Minnesota, Minneapolis, MN, United States.
University of Minnesota Medical Center · US

Funding

Women's CancerP30CA077598 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Douglas Yee · 1998 to 2026
$100.4M
Mass Spectrometric Analytical Collaborations with Members of the Masonic Cancer Center of the University of MinnesotaR50CA211256 · NCI · UNIVERSITY OF MINNESOTA · PI Peter William Villalta · 2016 to 2026
$2.1M
The DNA adductome of lung carcinogenesisR01CA220376 · NCI · UNIVERSITY OF MINNESOTA · PI BALBO, SILVIA · 2018 to 2022
$1.7M
NCI NIH HHS P30 CA077598NCI NIH HHS R01 CA220376NCI NIH HHS R50 CA211256
6 · The paper itself

Abstract

DNA can be damaged through covalent modifications of the nucleobases by endogenous processes. These modifications, commonly referred to as DNA adducts, can persist and may lead to mutations, and ultimately to the initiation of cancer. A screening methodology for the majority of known endogenous DNA adducts would be a powerful tool for investigating the etiology of cancer and for the identification of individuals at high-risk to the detrimental effects of DNA damage. This idea led to the development of a DNA adductomic approach using high resolution data-dependent scanning, an extensive MS

Indexed as

cancerDNA adductomicsDNA damageinflammationlipid peroxidationmass spectrometrytobacco carcinogens

Identifiers

PMID31709223
PMCPMC6822301
OpenAlexW2980520661

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.