Evidence map›Paper›PMID 31709196›Full record

ArticleFrontiers in cellular and infection microbiology2019

Drug Discovery and Repurposing Inhibits a Major Gut Pathogen-Derived Oncogenic Toxin.

Paul Metz, Martijn J H Tjan, Shaoguang Wu, Mehrosh Pervaiz, Susanne Hermans, Aishwarya Shettigar, Cynthia L Sears, Tina Ritschel, Bas E Dutilh, Annemarie Boleij

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. From gut to proteomics: the impact ofFrontiers in oncology · 2025
    Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Frontiers in pharmacology · 2024
    Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Paul MetzCentre for Molecular and Biomolecular Informatics, Radboud University Medical Center (Radboudumc), Nijmegen, Netherlands.
Martijn J H TjanDepartment of Pathology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center (Radboudumc), Nijmegen, Netherlands.
Shaoguang WuDivision of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Mehrosh PervaizCentre for Molecular and Biomolecular Informatics, Radboud University Medical Center (Radboudumc), Nijmegen, Netherlands.
Susanne HermansCentre for Molecular and Biomolecular Informatics, Radboud University Medical Center (Radboudumc), Nijmegen, Netherlands.
Aishwarya ShettigarDivision of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Cynthia L SearsDivision of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Tina RitschelCentre for Molecular and Biomolecular Informatics, Radboud University Medical Center (Radboudumc), Nijmegen, Netherlands.
Bas E DutilhCentre for Molecular and Biomolecular Informatics, Radboud University Medical Center (Radboudumc), Nijmegen, Netherlands.
Annemarie BoleijDepartment of Pathology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center (Radboudumc), Nijmegen, Netherlands.
Johns Hopkins Medicine · USRadboud University Nijmegen · NLRadboud Institute for Molecular Life Sciences · NLJohns Hopkins University · USRadboud University Medical Center · NL

Funding

GPR35: Role in Colonic Inflammation and OncogenesisR01CA179440 · NCI · JOHNS HOPKINS UNIVERSITY · PI SEARS, CYNTHIA · 2013 to 2016
$1.3M
NCI NIH HHS R01 CA179440
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Cell Transformation, NeoplasticDrug DiscoveryDrug RepositioningGastrointestinal MicrobiomeToxins, BiologicalCarcinogensEndotoxinsHumansMetalloendopeptidasesMolecular ConformationMolecular Docking SimulationMolecular Dynamics SimulationProtein BindingStructure-Activity RelationshipCarcinogensEndotoxinsfragilysinMetalloendopeptidasesToxins, Biologicalbacterial toxinBacteroides fragilis enterotoxinchenodeoxycholic acidcolorectal cancercomputational drug design and discoverydrug screeningenterotoxigenic Bacteroides fragilis (ETBF)inflammatory bowel disease (IBD)

Identifiers

PMID31709196
PMCPMC6823872
OpenAlexW2980526811

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.