Evidence map›Paper›PMID 31709121›Full record

ArticleStroke and vascular neurology2019

Lower lymphocyte to monocyte ratio is a potential predictor of poor outcome in patients with cerebral venous sinus thrombosis.

Shen Li, Kai Liu, Rui Zhang, Yuan Gao, Hui Fang, Xinjing Liu, Lulu Pei, L-Ying Richard Chou, Sheng Guan, Xinbin Guo and 3 more

Abstract read
In one paragraph

Article in Stroke and vascular neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Peripheral inflammation in spinocerebellar ataxia type 3: associations with genetic and clinical manifestations.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Can Complete Blood Count Picture Tell Us More About the Activity of Rheumatological Diseases?Clinical medicine insights. Arthritis and musculoskeletal disorders · 2022
    Article
  15. Inflammation in Cerebral Venous Thrombosis.Frontiers in immunology · 2022
    Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Shen Li *Department of Neurology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Kai Liu *Department of Neurology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Rui ZhangDepartment of Neurology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yuan GaoDepartment of Neurology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Hui FangDepartment of Neurology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Xinjing LiuDepartment of Neurology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Lulu PeiDepartment of Neurology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
L-Ying Richard ChouCardio-Neurology Clinic and Clinical Proteomics Research Center and Neuroprotection Research Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Sheng GuanDepartment of Neurology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Xinbin GuoDepartment of Neurology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Haowen XuDepartment of Neurology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Bo SongDepartment of Neurology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yuming XuDepartment of Neurology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Lymphocyte to monocyte ratio (LMR) is associated with functional outcome in patients with stroke. But the relationship between the LMR value and the prognosis of cerebral venous sinus thrombosis (CVST) has not been investigated. Methods: CVST patients, admitted to the First Affiliated Hospital of Zhengzhou University, were retrospectively identified from November 2010 to January 2017. Functional outcomes of patients were evaluated with the modified Rankin Scale (mRS). Patients were divided into good (mRS 0-2) and poor (mRS 3-6) outcomes groups. Univariate and multivariate Cox regression analyses were used to assess the relationship between LMR and the poor survival outcome. Results: A total of 228 patients were included of which 41 had poor outcomes (18.0%). The duration of follow-up was 22 months (6-66 months). LMR (2.3±1.2 vs 3.2±1.8, p<0.01) was significantly lower in the poor outcome group. Multivariate Cox regression analysis showed that LMR (HR 0.726, 95% CI 0.546 to 0.964, p=0.027) was a independent predictor of poor prognosis. Conclusions: LMR may be a predictor of poor prognosis in CVST patients.

Indexed as

LymphocytesMonocytesAdultDisability EvaluationFemaleFunctional StatusHumansLymphocyte CountMaleMiddle AgedPredictive Value of TestsRecovery of FunctionRetrospective StudiesSinus Thrombosis, IntracranialTime FactorsTreatment Outcomecerebral venous sinus thrombosislymphocyte to monocyte ratioprognosis

Identifiers

PMID31709121
PMCPMC6812640

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.