ArticleClinical & translational immunology2019
Immunological observations and transcriptomic analysis of trimester-specific full-term placentas from three Zika virus-infected women.
Article in Clinical & translational immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Analysis of Cytokine mRNA Expression During Zika Virus Infection InCurrent molecular medicine · 2026Article
- Neutrophils at the Maternal-Fetal Interface: Agents of Protection or Destruction?American journal of reproductive immunology (New York, N.Y. : 1989) · 2025Review
- Zika virus co-opts microRNA networks to persist in placental niches detected by spatial transcriptomics.American journal of obstetrics and gynecology · 2024Article
- Identification of novel anti-ZIKV drugs from viral-infection temporal gene expression profiles.Emerging microbes & infections · 2023Article
- SARS-CoV-2 niches in human placenta revealed by spatial transcriptomics.Med (New York, N.Y.) · 2023Article
- Zika virus impacts extracellular vesicle composition and cellular gene expression in macaque early gestation trophoblasts.Scientific reports · 2022Article
- Placental Alterations in a Chikungunya-Virus-Infected Pregnant Woman: A Case Report.Microorganisms · 2022Article
- Downregulation of transcriptional activity, increased inflammation, and damage in the placenta followingFrontiers in virology (Lausanne, Switzerland) · 2022Article
- Human Neutrophils Present Mild Activation by Zika Virus But Reduce the Infection of Susceptible Cells.Frontiers in immunology · 2022Article
- Comparison of rhesus and cynomolgus macaques as an infection model for COVID-19.Nature communications · 2021Article
- Placental Macrophage (Hofbauer Cell) Responses to Infection During Pregnancy: A Systematic Scoping Review.Frontiers in immunology · 2021Article
- Differential Type 1 IFN Gene Expression in CD14+ Placenta Cells Elicited by Zika Virus Infection During Pregnancy.Frontiers in virology (Lausanne, Switzerland) · 2021Article
- Zika Induces Human Placental Damage and Inflammation.Frontiers in immunology · 2020Article
Corrections and comments
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Authors and funding
22 authors at 9 institutions in 2 countries.
Funding
Abstract
objectivesEffects of Zika virus (ZIKV) infection on placental development during pregnancy are unclear.
methodsFull-term placentas from three women, each infected with ZIKV during specific pregnancy trimesters, were harvested for anatomic, immunologic and transcriptomic analysis.
resultsIn this study, each woman exhibited a unique immune response with raised IL-1RA, IP-10, EGF and RANTES expression and neutrophil numbers during the acute infection phase. Although ZIKV NS3 antigens co-localised to placental Hofbauer cells, the placentas showed no anatomic defects. Transcriptomic analysis of samples from the placentas revealed that infection during trimester 1 caused a disparate cellular response centred on differential eIF2 signalling, mitochondrial dysfunction and oxidative phosphorylation. Despite these, the babies were delivered without any congenital anomalies.
conclusionThese findings should translate to improve clinical prenatal screening procedures for virus-infected pregnant patients.
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