ArticleFrontiers in plant science2019
Stable Isotope-Assisted Plant Metabolomics: Combination of Global and Tracer-Based Labeling for Enhanced Untargeted Profiling and Compound Annotation.
Article in Frontiers in plant science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed.
- Mitochondrial proteostasis regulated by CRL5Communications biology · 2025Article
- Triple labeling of metabolites for metabolome analysis (TLEMMA): a stable isotope labeling approach for metabolite identification and network reconstruction.The Plant journal : for cell and molecular biology · 2025Article
- Accuracy, linearity, and statistical differences in comparative quantification in untargeted plant metabolomics using LC-ESI-Orbitrap-MS.Analytical and bioanalytical chemistry · 2025Article
- Tailored Mass Spectral Data Exploration Using the SpecXplore Interactive Dashboard.Analytical chemistry · 2024Article
- Identification of biological signatures of cruciferous vegetable consumption utilizing machine learning-based global untargeted stable isotope traced metabolomics.Frontiers in nutrition · 2024Article
- Untargeted Plant Metabolomics: Evaluation of Lyophilization as a Sample Preparation Technique.Metabolites · 2023Article
- Towards a broader view of the metabolome: untargeted profiling of soluble and bound polyphenols in plants.Analytical and bioanalytical chemistry · 2022Article
- Gramiketides, Novel Polyketide Derivatives ofJournal of fungi (Basel, Switzerland) · 2022Article
- CPExtract, a Software Tool for the Automated Tracer-Based Pathway Specific Screening of Secondary Metabolites in LC-HRMS Data.Analytical chemistry · 2022Article
- Untargeted Analysis ofMetabolites · 2021Article
- Metabolic source isotopic pair labeling and genome-wide association are complementary tools for the identification of metabolite-gene associations in plants.The Plant cell · 2021Article
- Comparing Stable Isotope Enrichment by Gas Chromatography with Time-of-Flight, Quadrupole Time-of-Flight, and Quadrupole Mass Spectrometry.Analytical chemistry · 2021Article
- Probing rapid carbon fixation in fast-growing seaweed Ulva meridionalis using stable isotopeScientific reports · 2020Article
- Enhanced Metabolome Coverage and Evaluation of Matrix Effects by the Use of Experimental-Condition-MatchedMetabolites · 2020Article
- Stable Isotope-Assisted Plant Metabolomics: Investigation of Phenylalanine-Related Metabolic Response in Wheat Upon Treatment With theFrontiers in plant science · 2019Article
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10 authors.
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Abstract
Untargeted approaches and thus biological interpretation of metabolomics results are still hampered by the reliable assignment of the global metabolome as well as classification and (putative) identification of metabolites. In this work we present an liquid chromatography-mass spectrometry (LC-MS)-based stable isotope assisted approach that combines global metabolome and tracer based isotope labeling for improved characterization of (unknown) metabolites and their classification into tracer derived submetabolomes. To this end, wheat plants were cultivated in a customized growth chamber, which was kept at 400 ± 50 ppm
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