Evidence map›Paper›PMID 31708923›Full record

ArticleFrontiers in immunology2019

Gut Antibody Deficiency in a Mouse Model of CVID Results in Spontaneous Development of a Gluten-Sensitive Enteropathy.

Ahmed Dawood Mohammed, Md A Wadud Khan, Ioulia Chatzistamou, Douja Chamseddine, Katie Williams-Kang, Mason Perry, Reilly Enos, Angela Murphy, Gregorio Gomez, Ahmed Aladhami and 6 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Microbiota-Immune Interactions Regulate Metabolic Disease.Journal of immunology (Baltimore, Md. : 1950) · 2021
    Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

Ahmed Dawood MohammedDepartment of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, SC, United States.
Md A Wadud KhanBiology Department, University of Texas at Arlington, Arlington, TX, United States.
Ioulia ChatzistamouDepartment of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, SC, United States.
Douja ChamseddineBiology Department, University of Texas at Arlington, Arlington, TX, United States.
Katie Williams-KangBiology Department, University of Texas at Arlington, Arlington, TX, United States.
Mason PerryBiology Department, University of Texas at Arlington, Arlington, TX, United States.
Reilly EnosDepartment of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, SC, United States.
Angela MurphyDepartment of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, SC, United States.
Gregorio GomezDepartment of Biomedical Sciences, College of Medicine, University of Houston, Houston, TX, United States.
Ahmed AladhamiDepartment of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, SC, United States.
Carole A OskeritzianDepartment of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, SC, United States.
Amy JollyDepartment of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, SC, United States.
Yan ChangCollege of Nursing and Health Innovation, University of Texas at Arlington, Arlington, TX, United States.
Shuqian HeCollege of Nursing and Health Innovation, University of Texas at Arlington, Arlington, TX, United States.
Zui PanCollege of Nursing and Health Innovation, University of Texas at Arlington, Arlington, TX, United States.
Jason L KubinakDepartment of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, SC, United States.
University of South Carolina · USThe University of Texas at Arlington · USUniversity of Houston · US

Funding

Targeting NMDA Receptors and Brain Estradiol to Rescue Memory in Aging FemalesP20GM109091 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI RONINSON, IGOR B · 2014 to 2024
$25.2M
Targeting early ceramide elevation in pre-symptomatic eczemaP20GM103641 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI ENOS, REILLY, NAGARKATTI, PRAKASH S · 2012 to 2023
$20.7M
Mechanism of MHC heterozygote advantage during anti-commensal germinal center B cell selectionR21AI142409 · NIAID · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI KUBINAK, JASON L · 2019 to 2020
$410k
MicroRNAs in atopic dermatitis pathogenesis: a role for mast cell and sphingosine-1-phosphate?R21AR067996 · NIAMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI OSKERITZIAN, CAROLE A · 2016 to 2017
$323k
Exploring how B cell Maturation Pathways Influence Microbiota Composition and Host HealthK22AI123481 · NIAID · UNIVERSITY OF TEXAS ARLINGTON · PI KUBINAK, JASON L · 2017 to 2018
$263k
NIAID NIH HHS K22 AI123481NIAID NIH HHS R21 AI142409NIAMS NIH HHS R21 AR067996NIGMS NIH HHS P20 GM103641NIGMS NIH HHS P20 GM109091
6 · The paper itself

Abstract

Primary immunodeficiencies are heritable disorders of immune function. CD19 is a B cell co-receptor important for B cell development, and CD19 deficiency is a known genetic risk factor for a rare form of primary immunodeficiency known as "common variable immunodeficiency" (CVID); an antibody deficiency resulting in low levels of serum IgG and IgA. Enteropathies are commonly observed in CVID patients but the underlying reason for this is undefined. Here, we utilize CD19

Indexed as

AnimalsAnti-Bacterial AgentsAntibodiesAntibodies, BacterialAntigens, CD19B-LymphocytesCeliac DiseaseCommon Variable ImmunodeficiencyDisease Models, AnimalFemaleGastrointestinal MicrobiomeGene Expression ProfilingGlutensImmunoglobulin AIntestinal AbsorptionIntestinesAnti-Bacterial AgentsAntibodiesAntibodies, BacterialAntigens, CD19CD19 antigen, mouseGlutensImmunoglobulin AMetronidazoleCVIDCVID enteropathydysbiosisgluten sensitivityprimary immunodeficiency

Identifiers

PMID31708923
PMCPMC6820504
OpenAlexW2981781121

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.