Evidence map›Paper›PMID 31708922›Full record

ArticleFrontiers in immunology2019

Pregnancy-Induced Alterations in NK Cell Phenotype and Function.

Mathieu Le Gars, Christof Seiler, Alexander W Kay, Nicholas L Bayless, Elina Starosvetsky, Lindsay Moore, Shai S Shen-Orr, Natali Aziz, Purvesh Khatri, Cornelia L Dekker and 4 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03196245 (NK Cell Mediated Influenza Immunity During Pregnancy), which is not on this map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03196245 terminatednot on this map

NK Cell Mediated Influenza Immunity During Pregnancy

TypeobservationalSponsorStanford UniversityRan2012 to 2019Enrolled94ConditionsPregnancy Related, Influenza, HumanArmsThere is no intervention.
3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 52 citations in OpenAlex.

  1. Tuberculosis in Pregnancy: Challenges of Immune Protection.The Journal of infectious diseases · 2026
    Review
  2. Article
  3. Article
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  5. Article
  6. Review
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  12. Article
  13. Article
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  16. Article
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  18. Article
  19. Viral Infections During Pregnancy: The Big Challenge Threatening Maternal and Fetal Health.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Mathieu Le GarsDepartment of Medicine, Stanford University, Palo Alto, CA, United States.
Christof SeilerDepartment of Statistics, Stanford University, Palo Alto, CA, United States.
Alexander W KayDepartment of Pediatrics, Stanford University, Palo Alto, CA, United States.
Nicholas L BaylessDepartment of Stanford Immunology Program, Stanford University, Palo Alto, CA, United States.
Elina StarosvetskyFaculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel.
Lindsay MooreFaculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel.
Shai S Shen-OrrFaculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel.
Natali AzizDepartment of Obstetrics and Gynecology, Stanford Prevention Research Center, Stanford University School of Medicine, Stanford University, Palo Alto, CA, United States.
Purvesh KhatriDepartment of Medicine, Stanford University, Palo Alto, CA, United States.
Cornelia L DekkerDepartment of Statistics, Stanford University, Palo Alto, CA, United States.
Gary E SwanDepartment of Obstetrics and Gynecology, Stanford Prevention Research Center, Stanford University School of Medicine, Stanford University, Palo Alto, CA, United States.
Mark M DavisDepartment of Microbiology and Immunology, Stanford University, Palo Alto, CA, United States.
Susan HolmesDepartment of Pediatrics, Stanford University, Palo Alto, CA, United States.
Catherine A BlishDepartment of Medicine, Stanford University, Palo Alto, CA, United States.
Stanford University · USTechnion – Israel Institute of Technology · IL

Funding

Using a tonsil organoid system to probe conditions for the induction of protective antibody and T cell responses to influenza.U19AI057229 · NIAID · STANFORD UNIVERSITY · PI Mark Morris Davis · 2003 to 2026
$88.5M
Stanford Center for Clinical & Translational Education and Research (Spectrum)UL1TR003142 · NCATS · STANFORD UNIVERSITY · PI O'HARA, RUTH M · 2019 to 2023
$45.0M
Stanford Center for Clinical and Translational Education and Research (SCCTER)UL1UL1RR025744 · NCRR · STANFORD UNIVERSITY · PI GREENBERG, HARRY BERNARD · 2008 to 2011
$22.4M
Functional and transcriptional signatures of preterm birthF31HD089675 · NICHD · STANFORD UNIVERSITY · PI BAYLESS, NICHOLAS LOGAN · 2016 to 2016
$25k
NCATS NIH HHS UL1 TR003142NCRR NIH HHS UL1 RR025744NIAID NIH HHS T32 AI78896-05NIAID NIH HHS U19 AI057229NICHD NIH HHS F31 HD089675
6 · The paper itself

Abstract

Pregnant women are particularly susceptible to complications of influenza A virus infection, which may result from pregnancy-induced changes in the function of immune cells, including natural killer (NK) cells. To better understand NK cell function during pregnancy, we assessed the ability of the two main subsets of NK cells, CD56

Indexed as

AdultCells, CulturedCohort StudiesFemaleHumansKiller Cells, NaturalPregnancyPregnancy Complications, InfectiousPregnancy Complications, Neoplasticcancer cellsinfluenza virusNK cellsNK repertoirepregnancy

Identifiers

PMID31708922
PMCPMC6820503
OpenAlexW2981542404

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.