Evidence map›Paper›PMID 31708913›Full record

ArticleFrontiers in immunology2019

Macrophage Migration Inhibitory Factor (MIF) Is Essential for Type 2 Effector Cell Immunity to an Intestinal Helminth Parasite.

Kara J Filbey, Fumi Varyani, Yvonne Harcus, James P Hewitson, Danielle J Smyth, Henry J McSorley, Alasdair Ivens, Susanne Nylén, Martin Rottenberg, Stephan Löser and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Modulation of the Immune Response by Nematode Derived Molecules.International journal of molecular sciences · 2025
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Macrophage migration inhibitory factor contributes to immunopathogenesis duringFrontiers in cellular and infection microbiology · 2022
    Article
  17. Macrophage migration inhibitory factor in Nodding syndrome.PLoS neglected tropical diseases · 2021
    Article
  18. Enteric Tuft Cells in Host-Parasite Interactions.Pathogens (Basel, Switzerland) · 2021
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Kara J FilbeyInstitute of Immunology and Infection Research, University of Edinburgh, Edinburgh, United Kingdom.
Fumi VaryaniInstitute of Immunology and Infection Research, University of Edinburgh, Edinburgh, United Kingdom.
Yvonne HarcusInstitute of Immunology and Infection Research, University of Edinburgh, Edinburgh, United Kingdom.
James P HewitsonInstitute of Immunology and Infection Research, University of Edinburgh, Edinburgh, United Kingdom.
Danielle J SmythWellcome Centre for Integrative Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom.
Henry J McSorleyCentre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom.
Alasdair IvensInstitute of Immunology and Infection Research, University of Edinburgh, Edinburgh, United Kingdom.
Susanne NylénDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
Martin RottenbergDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
Stephan LöserWellcome Centre for Integrative Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom.
Rick M MaizelsWellcome Centre for Integrative Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom.
University of Edinburgh · GBKarolinska Institutet · SEWellcome Centre for Molecular Parasitology · GBUniversity of Glasgow · GB

Funding

Medical Research Council MC_PC_18048Wellcome TrustWellcome Trust 104111Wellcome Trust 106122Wellcome Trust 107490
6 · The paper itself

Abstract

Immunity to intestinal helminths is known to require both innate and adaptive components of the immune system activated along the Type 2 IL-4R/STAT6-dependent pathway. We have found that macrophage migration inhibitory factor (MIF) is essential for the development of effective immunity to the intestinal helminth

Indexed as

Immunity, CellularMacrophage ActivationAnimalsIntramolecular OxidoreductasesMacrophage Migration-Inhibitory FactorsMacrophagesMice, Inbred BALB CMice, Mutant StrainsNematospiroides dubiusStrongylida InfectionsT-Lymphocytes, RegulatoryIntramolecular OxidoreductasesMacrophage Migration-Inhibitory FactorsMif protein, mousearginaseeosinophilHeligmosmoides polygyrushelminthsinnate immunitymacrophage

Identifiers

PMID31708913
PMCPMC6821780
OpenAlexW2981576432

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.