Evidence map›Paper›PMID 31708871›Full record

ReviewFrontiers in endocrinology2019

Vitamin D Binding Protein and the Biological Activity of Vitamin D.

Rene F Chun, Albert Shieh, Carter Gottlieb, Vahe Yacoubian, Jeffrey Wang, Martin Hewison, John S Adams

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in endocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 2 pooled it
9.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 2 syntheses or guidelines pooled it, 109 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Review
  6. Article
  7. Content of Vitamin DMetabolites · 2026
    Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Understanding the role of vitamin D in osteosarcoma: A narrative review.Medical oncology (Northwood, London, England) · 2025
    Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Rene F ChunDepartment of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States.
Albert ShiehDepartment of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States.
Carter GottliebDepartment of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States.
Vahe YacoubianDepartment of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States.
Jeffrey WangDepartment of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States.
Martin HewisonInstitute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom.
John S AdamsDepartment of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States.
University of California, Los Angeles · USUniversity of Birmingham · GB

Funding

DBP and the bioavailability and function of vitamin DR01AR063910 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ADAMS, JOHN S, HEWISON, MARTIN · 2013 to 2017
$1.8M
Impact of ethnicity in the gut microbiome in response to oral vitamin D replacementR21AR073018 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ADAMS, JOHN S · 2017 to 2017
$302k
NIAMS NIH HHS R01 AR063910NIAMS NIH HHS R21 AR073018
6 · The paper itself

Abstract

Vitamin D has a long-established role in bone health. In the last two decades, there has been a dramatic resurgence in research interest in vitamin D due to studies that have shown its possible benefits for non-skeletal health. Underpinning the renewed interest in vitamin D was the identification of the vital role of intracrine or localized, tissue-specific, conversion of inactive pro-hormone 25-hydroxyvitamin D [25(OH)D] to active 1,25-dihydroxyvitamin D [1,25(OH)

Indexed as

boneCYP27B1DBPfree vitamin DimmunologyVDRvitamin D

Identifiers

PMID31708871
PMCPMC6821678
OpenAlexW2981852166

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.