ArticleFrontiers in physiology2019
Muscle-Specific Sensitivity to Voluntary Physical Activity and Detraining.
Article in Frontiers in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Mitochondrial haplotype and sex modulate responses to endurance exercise training.The Journal of physiology · 2025Article
- Voluntary wheel running promotes lymphangiogenesis in slow-twitch muscle in young mice.Frontiers in physiology · 2025Article
- Synergy between time-restricted feeding and time-restricted running is necessary to shift the muscle clock in male wistar rats.Neurobiology of sleep and circadian rhythms · 2024Article
- Temporal expression of mitochondrial life cycle markers during acute and chronic overload of rat plantaris muscles.Frontiers in physiology · 2024Article
- Long-term detraining reverses the improvement of lifelong exercise on skeletal muscle ferroptosis and inflammation in aging rats: fiber-type dependence of the Keap1/Nrf2 pathway.Biogerontology · 2023Article
- Aerobic Exercise Ameliorates Muscle Atrophy Induced by MethylglyoxalBiomolecules & therapeutics · 2023Article
- Protein signalling in response to ex vivo dynamic contractions is independent of training status in rat skeletal muscle.Experimental physiology · 2022Article
- MOTS-c increases in skeletal muscle following long-term physical activity and improves acute exercise performance after a single dose.Physiological reports · 2022Article
- TLR4-Mediated Inflammatory Responses Regulate Exercise-Induced Molecular Adaptations in Mouse Skeletal Muscle.International journal of molecular sciences · 2022Article
- Strength Level of Professional Elite Soccer Players after the COVID-19 Lockdown Period: A Retrospective Double-Arm Cohort Study.Journal of sports medicine (Hindawi Publishing Corporation) · 2022Article
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Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aerobic physical activity triggers adaptations in skeletal muscle including a fast-to-slow shift in myosin heavy chain (MHC) isoforms, an enhanced capillary network, and mitochondrial biogenesis to meet increased demands placed upon this tissue. Although the magnitude of these responses appears to be dependent on muscle phenotype as well as training volume and/or intensity, the whole-muscle response to detraining remains mostly unexplored. Here, we hypothesized that the shifts toward slower MHC phentotype and the increased capillarity and mitochondrial oxidative markers induced with training would return toward sedentary (SED) control levels sooner in the fast plantaris than in the slow soleus muscle as a result of detraining. Soleus and plantaris muscles from 8-week (TR 8wk) voluntarily running adult female Sprague-Dawley rats were compared to muscles from SED and detrained rats (DETR) (4 weeks voluntary running followed by 4 weeks of reduced activity), which were subdivided into low- (DETR Lo) and high-running-distance (DETR Hi) groups. We show that maintaining the fast-to-slow MHC isoform shift required consistent aerobic training in the soleus and plantaris muscles: detraining clearly abolished any fast-to-slow gains in the plantaris, whereas the training volume in DETR Hi rats appeared to influence the MHC return to basal levels in the soleus. Total capillary number (per mm
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