Evidence map›Paper›PMID 31708792›Full record

ArticleFrontiers in physiology2019

A Novel Model of Mixed Vascular Dementia Incorporating Hypertension in a Rat Model of Alzheimer's Disease.

Paul Denver, Heather D'Adamo, Shuxin Hu, Xiaohong Zuo, Cansheng Zhu, Chihiro Okuma, Peter Kim, Daniel Castro, Mychica R Jones, Carmen Leal and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 34 citations in OpenAlex.

  1. A review of animal models of vascular dementia.Molecular biology reports · 2026
    Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. AQP4 Aggravates Cognitive Impairment in Sepsis-Associated Encephalopathy through Inhibiting NaAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Emerging roles for AQP in mammalian extracellular vesicles.Biochimica et biophysica acta. Biomembranes · 2022
    Review
  14. Aquaporin-4 and Cognitive Disorders.Aging and disease · 2022
    Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Clearance Systems in the Brain, From Structure to Function.Frontiers in cellular neuroscience · 2021
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Paul DenverDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Heather D'AdamoDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Shuxin HuDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Xiaohong ZuoDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Cansheng ZhuDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Chihiro OkumaDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Peter KimDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Daniel CastroDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Mychica R JonesDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Carmen LealDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Marisa MekkittikulDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Elham GhadishahDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Bruce TeterDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Harry V VintersDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Gregory Michael ColeDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Sally A FrautschyDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
University of California, Los Angeles · USVA Greater Los Angeles Healthcare System · USGeriatric Research Education and Clinical Center · US

Funding

Metabolic and Vascular Factors in tau pathogenesisR01AG066212 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FRAUTSCHY, SALLY ANN · 2020 to 2024
$3.4M
BLRD VA I01 BX001257BLRD VA I01 BX003485BLRD VA I01 BX005919NIA NIH HHS R01 AG066212RRD VA I01 RX000669
6 · The paper itself

Abstract

Alzheimer's disease (AD) and mixed dementia (MxD) comprise the majority of dementia cases in the growing global aging population. MxD describes the coexistence of AD pathology with vascular pathology, including cerebral small vessel disease (SVD). Cardiovascular disease increases risk for AD and MxD, but mechanistic synergisms between the coexisting pathologies affecting dementia risk, progression and the ultimate clinical manifestations remain elusive. To explore the additive or synergistic interactions between AD and chronic hypertension, we developed a rat model of MxD, produced by breeding APPswe/PS1ΔE9 transgenes into the stroke-prone spontaneously hypertensive rat (SHRSP) background, resulting in the SHRSP/FAD model and three control groups (FAD, SHRSP and non-hypertensive WKY rats,

Indexed as

Alzheimer diseasecerebrovascular integrityrat modeltau pathogenesisvascular dementia

Identifiers

PMID31708792
PMCPMC6821690
OpenAlexW2981430560

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.