Evidence map›Paper›PMID 31708747›Full record

ReviewFrontiers in cellular neuroscience2019

Fluorescent Biosensors for Neurotransmission and Neuromodulation: Engineering and Applications.

Anna V Leopold, Daria M Shcherbakova, Vladislav V Verkhusha

Abstract readReview
In one paragraph

Review in Frontiers in cellular neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Engineering signalling pathways in mammalian cells.Nature biomedical engineering · 2024
    Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Anna V LeopoldMedicum, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Daria M ShcherbakovaDepartment of Anatomy and Structural Biology, Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine, Bronx, NY, United States.
Vladislav V VerkhushaMedicum, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

Funding

Near-Infrared Fluorescent Proteins, Biosensors and Optogenetic ToolsR35GM122567 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI Vladislav Verkhusha · 2017 to 2026
$4.3M
A system for whole-brain recording and control of activated neurons with near-infrared lightR21EY030705 · NEI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI SHCHERBAKOVA, DARIA · 2019 to 2019
$503k
NEI NIH HHS R21 EY030705NIGMS NIH HHS R35 GM122567
6 · The paper itself

Abstract

Understanding how neuronal activity patterns in the brain correlate with complex behavior is one of the primary goals of modern neuroscience. Chemical transmission is the major way of communication between neurons, however, traditional methods of detection of neurotransmitter and neuromodulator transients in mammalian brain lack spatiotemporal precision. Modern fluorescent biosensors for neurotransmitters and neuromodulators allow monitoring chemical transmission

Indexed as

dopamineGABAGltIglutamateGPCRneural circuitnorepinephrineserotonin

Identifiers

PMID31708747
PMCPMC6819510

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.